Click here to view publications by Dr. Nicholas Chiorazzi, MD, in PubMed.

Chu CC, Catera R, Hatzi K, Yan X-J, Zhang l, Wang XB, Fales HM, Allen SL, Kolitz JE, Rai KR, Chiorazzi N. (2008) Chronic lymphocytic leukemia antibodies with a common stereotypic rearrangement recognize non-muscle myosin heavy chain IIA. Blood. 112:5122-5129.

Grubor VD, Krasnitz A, Troge JE, Meth JL, Lakshmi B, Kendall JT, Yamrom B, Alex G, Pai D, Navin N, Hufnagel LA, Lee Y-H,  Cook K, Allen SL, Rai KR, Damle RN, Calissano C, Chiorazzi N, Wigler MH, Esposito D. (2009) Novel genomic alterations and clonal evolution in Chronic Lymphocytic Leukemia  revealed by Representational Oligonucleotide Microarray Analysis (ROMA). Blood. 113: 1294-303

Catera R, Silverman GJ, Hatzi K, Seiler TM, Didier S, Zhang L, Herve M, Meffre E, Oscier DG, Vlassara H, Chen Y, Allen SL, Rai KR, Chu CC, Chiorazzi N. (2008) Chronic lymphocytic leukemia cells recognize conserved epitopes associated with apoptosis and chemical modifications. Mol Med. 14: 665-674.

McCarthy BA, Boyle E, Wang XP, Guzowski D, Paul S, Catera R, Trott J, Yan X-J, Croce CM, Yancopoulos S, Messmer BT, Allen SL, Rai KR, Chiorazzi N. (2008) Surface expression of Bcl2 in chronic lymphocytic leukemia and other B-cell leukemias and lymphomas without a breakpoint t(14:18). Mol Med. 14: 618-627.

Li F-J, Ding S, Pan J, Shakhmatov MA, Kashentseva E, Wu J, Li Y, Soong S-J,  Chiorazzi N, Davis RS. (2008) FCRL2 expression predicts IgVH mutation status and clinical progression in chronic lymphocytic leukemia.  Blood. 112:179-187.

Damle RN, Temburni S, Calissano C, Yancopoulos S, Banapour T, Sison C, Allen SL, Rai KR, Chiorazzi N. (2007) CD38 expression labels an activated subset within chronic lymphocytic leukemia clones enriched in proliferating B cells.  Blood. 110: 3352-3359.

Chiorazzi N, Ferrarini M. (2006) Evolving view of the in-vivo kinetics of chronic lymphocytic leukemia B cells. Hematology (Am Soc Hematol Educ Program). 273-278.

Ghiotto F, Fais F, Albesiano E, Sison C, Valetto A, Gaidano G, Reinhardt J, Kolitz JE, Rai KR, Allen SL, Ferrarini M, Chiorazzi N. (2006) Similarities and differences between the light and heavy chain Ig variable region gene repertoires in chronic lymphocytic leukemia.  Mol Med. 12: 300-308.

Yan X-J, Albesiano E, Zanesi N, Yancopoulos S, Sawyer A, Romano E, Petlickovski A, Efremov DG, Croce CM, Chiorazzi N. (2006) B cell receptors in TCL1 transgenic mice resemble those of aggressive, treatment-resistant human chronic lymphocytic leukemia.  Proc Natl Acad Sci USA. 103:11713-11718.

Herve M, Xu K, Ng Y-S, Wardemann H, Albesiano E, Messmer BT, Chiorazzi N, Meffre E. (2005) Unmutated and mutated chronic lymphocytic leukemia derive from self-reactive B cell precursors despite expressing different antibody reactivity. J Clin Invest. 115: 1636-1643.

Messmer BT, Messmer D, Allen SL, Kolitz JE, Kudalkar P, Cesar D, Murphy EJ, Koduru P, Ferrarini M, Zupo S, Cutrona G, Damle RN, Wasil T, Rai KR, Hellerstein MK, Chiorazzi N. (2005) In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells. J Clin Invest. 115: 755-764.

Chiorazzi N, Rai KR, Ferrarini M. (2005) Mechanisms of Disease. Chronic Lymphocytic Leukemia. N Engl J Med. 352: 804-815.

Messmer BT, Albesiano E, Efremov DG, Ghiotto F, Allen SL, Kolitz J, Damle R, Fais F, Messmer D, Rai KR, Ferrarini M, Chiorazzi N. (2004) Distinct sets of stereotyped antigen receptors indicate the limited primary structural diversity in antigen-binding sites of CLL B cells.  J Exp Med. 200: 519-525.

Messmer BT, Albesiano E, Messmer D, Chiorazzi N. (2003) The pattern and distribution of immunoglobulin VH gene mutations in chronic lymphocytic leukemia B cells are consistent with the canonical somatic hypermutation process. Blood. 103: 3490-3495.
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Ghiotto F, Fais F, Valetto A, Albesiano E, Hashimoto S, Dono M, Ikematsu H, Allen SL, Kolitz J, Rai KR, Nardini M, Tramontano A, Ferrarini M, Chiorazzi N. (2004) Remarkably similar antigen receptors among a subset of patients with chronic lymphocytic leukemia. J Clin Invest. 113: 1008-1016.

Damle RN, Batliwalla FM, Ghiotto F, Valetto A, Albesiano E, Sison C, Allen SL, Kolitz J, Vinciguerra VP, Kudalkar P, Wasil T, Rai KR, Ferrarini M, Gregersen PK, Chiorazzi N. (2004) Telomere length and telomerase activity delineate distinctive replicative features of the B-CLL subgroups defined by Ig V gene mutations. Blood. 103: 375-382.

Chiorazzi N, Messmer BT, Damle RN, Alllen SL, Rai KR, Ferrarini M. (2003) Unraveling the biology of chronic lymphocytic leukemia. Hematology (Am Soc Hematol Educ Program). 153-159.

Albesiano E, Messmer BT, Damle RN, Allen SL, Rai KR, Chiorazzi N. (2003) Activation-induced cytidine deaminase in chronic lymphocytic leukemia B cells: expression as multiple forms in a dynamic, variably sized fraction of the clone. Blood. 102: 3333-3339.

Chiorazzi N, Ferrarini M. (2003) B Cell Chronic Lymphocytic Leukemia: Lessons learned from studies of the B cell antigen receptor. Annu Rev Immunol. 21: 841-894.

Damle RN, Ghiotto F, Valetto A, Albesiano E, Fais F, Yan X-J, Sison CP, Allen SL, Kolitz J, Schulman P, Vinciguerra VP, Budde P, Frey J, Rai KR, Ferrarini M, Chiorazzi N. (2002) B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes. Blood. 99: 4087-4093.

Gurrieri C, McGuire P, Zan H, Yan X-J, Cerutti A, Albesiano E, Allen SL, Vinciguerra V, Rai KR, Ferrarini M, Casali P, Chiorazzi N. (2002) Chronic lymphocytic leukemia B cells can undergo somatic hypermutation and intraclonal Ig VHDJH gene diversification. J Exp Med. 196:629-639.

Damle RN, Wasil T, Fais F, Ghiotto F, Valetto A, Allen SL, Buchbinder A, Budman D, Dittmar K, Kolitz J, Lichtman SM, Schulman P, Vinciguerra VP, Rai KR, Ferrarini M, Chiorazzi N. (1999) Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood. 94: 1840-1847.

Fais F, Ghiotto F, Hashimoto S, Sellars B, Allen SL, Schulman P, Vinciguerra VP, Rai K, Rassenti LZ, Kipps TJ, Dighiero G, Schroeder HW, Jr., Ferrarini M, Chiorazzi N. (1998) Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors.  J Clin Invest. 102: 1515-1525.

Fais F, Sellars B, Ghiotto F, Yan X-J, Dono M, Allen SL, Budman D, Dittmar K, Kolitz J, Lichtman SM, Schulman P, Schuster M, Vinciguerra VP, Rai K, Stevenson F, Gregersen PK, Ferrarini M, Chiorazzi N. (1996) Molecular examples of in vivo isotype class switching in IgM+ chronic lymphocytic leukemia B cells.  J Clin Invest. 98: 1659-1666.

Hashimoto S, Wakai M, Allen SL, Lichtman SM, Schulman P, Vinciguerra VP, Ferrarini M, Silver J, Chiorazzi N. (1995) Somatic diversification and selection of immunoglobulin heavy and light chain variable region genes in IgG+, CD5+ chronic lymphocytic leukemia B cells.  J Exp Med. 181: 1507-1517.

Wakai M, Hashimoto S, Sthoeger ZM, Allen SL, Lichtman SM, Schulman P, Vinciguerra VP, Diamond B, Ferrarini M, Chiorazzi N. (1994) IgG+, CD5+ human chronic lymphocytic leukemia B cells. I. Production of IgG antibodies that exhibit diminished autoreactivity and IgG subclass skewing.  Autoimmunity. 19: 39-48.

Sthoeger ZM, Wakai M, Tse DB, Vinciguerra VP, Allen SL, Budman DR, Lichtman SM, Schulman P, Weiselberg LR, Chiorazzi N. (1989) Production of autoantibodies by CD5-expressing B lymphocytes from patients with chronic lymphocytic leukemia.  J Exp Med. 169: 255-268.
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