Biorepository and Sample Acquisition Core — The Biorepository was designed to collect, process, and distribute large numbers of high quality research specimens quickly and efficiently. The data that is collected is primarily human DNA from whole blood along with other human specimen types. The data are collected, processed, stored and later distributed to support a large number of research studies. Biobanking of other specimen types include cells, RNA, serum, plasma and tissue. The Biorepository serves as a storage facility for tracking specimen inventory using bar code technologies. The Biorepository also conducts most operations using modern laboratory automation and robotics, an efficient way to avoid processing errors inherent in the handling of larger numbers of specimens.

Molecular Biology Core — The Molecular Biology Core is a collaborative program in genetics. Scientists have access to high throughput genetic mapping technology that includes SNP and microsatellite analysis. Investigators can also carry out gene expression arrays and analysis of methylation differences across the human genome. The facility offers help to researchers from a variety of other scientific fields who want to add a genetic component to their research, or who wish to examine the patterns of gene expression and regulation in various cells and tissues. The facility makes extensive use of robotic systems that facilitate rapid production of data and allow scientists more time to focus on data analysis. The core also offers consultation on assay development, validation, and configuration of assays for high throughput screening.

Imaging Core — The Imaging Core occupies 2,500 square feet and is staffed by three biophysicists and two computer scientists/data analysts. The close proximity of the GCRC to the positron emission tomography (PET) imaging laboratory and the new high field magnetic resonance imaging (MRI) facility is a significant advantage to GCRC investigators.

Biostatistics Core — At the heart of basic and clinical biomedical research is the need to carefully gather data, analyze it and interpret it in order to validate the stated objectives of a research study. The Biostatistics Unit provides support to investigators in the design, implementation, data management, statistical analysis, and publication of basic science and clinical research studies. This is accomplished by applying established statistical and mathematical methods to the analysis of research data, as well as developing new methods to address complex research problems.

Biomedical Informatics Core  -- The Biomedical Informatics Core was developed to automate the standard laboratory processes of data collection as well as the command and control of robotic systems. The core also supports clinical and medical informatics, clinical annotation of Biorepository human specimens and tissues collections, large-scale data management and web based software development for data capture and management.