Click here to see publications by Haichao Wang, MD, in PubMed.

Botchkina GI, Zuniga ES, Das M, Wang Y, Wang H, Zhu S, Savitt AG, Rowehl RA, Leyfman Y, Ju J, Shroyer K and Ojima I. (2010) New-generation taxoid SB-T-1214 inhibits stem cell-related gene expression in 3D cancer spheroids induced by purified colon tumor-initiating cells. Mol Cancer. 9:192: 192.

Kang R, Tang D, Yu Y, Wang Z, Hu T, Wang H and Cao L (2010) WAVE1 regulates Bcl-2 localization and phosphorylation in leukemia cells. Leukemia. 24: 177-186.

Wang H, Li W, Zhu S, Li J, D'Amore J, Ward MF, Yang H, Wu R, Jahnen-Dechent W, Tracey KJ, Wang P and Sama AE. (2010) Peripheral administration of fetuin-A attenuates early cerebral ischemic injury in rats. J Cereb Blood Flow Metab. 30: 493-504.

Yang H, Hreggvidsdottir HS, Palmblad K, Wang H, Ochani M, Li J, Lu B, Chavan S, Rosas-Ballina M, Al Abed Y, Akira S, Bierhaus A, Erlandsson-Harris H, Andersson U and Tracey KJ. (2010) A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release. Proc Natl Acad Sci U S A. 107: 11942-11947.

Miksa M, Wu R, Dong W, Komura H, Amin D, Ji Y, Wang Z, Wang H, Ravikumar TS, Tracey KJ and Wang P. (2009) Immature dendritic cell-derived exosomes rescue septic animals via milk fat globule epidermal growth factor-factor VIII [corrected]. J Immunol. 183: 5983-5990.

Tang D, Kang R, Xiao W, Zhang H, Lotze MT, Wang H and Xiao X. (2009) Quercetin prevents LPS-induced high-mobility group box 1 release and proinflammatory function. Am J Respir Cell Mol Biol. 41: 651-660.

Wu R, Dong W, Qiang X, Wang H, Blau SA, Ravikumar TS and Wang P. (2009) Orexigenic hormone ghrelin ameliorates gut barrier dysfunction in sepsis in rats. Crit Care Med. 37: 2421-2426.

Zhu S, Ashok M, Li J, Li W, Yang H, Wang P, Tracey KJ, Sama AE and Wang H. (2009) Spermine protects mice against lethal sepsis partly by attenuating surrogate inflammatory markers. Mol Med. 15: 275-282.

Huston JM, Wang H, Ochani M, Ochani K, Rosas-Ballina M, Gallowitsch-Puerta M, Ashok M, Yang L, Tracey KJ and Yang H. (2008) Splenectomy protects against sepsis lethality and reduces serum HMGB1 levels. J Immunol. 181: 3535-3539.

Tang D, Kang R, Cao L, Zhang G, Yu Y, Xiao W, Wang H and Xiao X. (2008) A pilot study to detect high mobility group box 1 and heat shock protein 72 in cerebrospinal fluid of pediatric patients with meningitis. Crit Care Med. 36: 291-295.

Wang H, Zhu S, Zhou R, Li W and Sama AE. (2008) Therapeutic potential of HMGB1-targeting agents in sepsis. Expert Rev Mol Med. 10:e32.: e32.

Wang H, Zhu S, Ward MF, Gong J and Sama AE. (2008) Hyperglycemia aggravates endotoxin-induced high mobility group box 1 protein release: yet another reason not to be too sweet. Crit Care Med. 36: 2475-2476.

Ivanov S, Dragoi AM, Wang X, Dallacosta C, Louten J, Musco G, Sitia G, Yap GS, Wan Y, Biron CA, Bianchi ME, Wang H and Chu WM. (2007) A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA. Blood. 110: 1970-1981.

Li W, Ashok M, Li J, Yang H, Sama AE and Wang H. (2007) A Major Ingredient of Green Tea Rescues Mice from Lethal Sepsis Partly by Inhibiting HMGB1. PLoS ONE. 2: e1153.

Li W, Li J, Ashok M, Wu R, Chen D, Yang L, Yang H, Tracey KJ, Wang P, Sama AE and Wang H. (2007) A cardiovascular drug rescues mice from lethal sepsis by selectively attenuating a late-acting proinflammatory mediator, high mobility group box 1. J Immunol. 178: 3856-3864.

Tang D, Kang R, Xiao W, Wang H, Calderwood SK and Xiao X. (2007) The anti-inflammatory effects of heat shock protein 72 involve inhibition of high-mobility-group box 1 release and proinflammatory function in macrophages. J Immunol. 179: 1236-1244.

Tang D, Kang R, Xiao W, Wang H, Calderwood SK and Xiao X. (2007) The Anti-inflammatory Effects of Heat Shock Protein 72 Involve Inhibition of High-Mobility-Group Box 1 Release and Proinflammatory Function in Macrophages. J Immunol. 179: 1236-1244.

Tang D, Kang R, Xiao W, Jiang L, Liu M, Shi Y, Wang K, Wang H and Xiao X. (2007) Nuclear heat shock protein 72 as a negative regulator of oxidative stress (hydrogen peroxide)-induced HMGB1 cytoplasmic translocation and release. J Immunol. 178: 7376-7384.

Li W, Sama AE and Wang H. (2006) Role of HMGB1 in cardiovascular diseases. Curr Opin Pharmacol. 6: 130-135.

Qin S, Wang H, Yuan R, Li H, Ochani M, Ochani K, Rosas-Ballina M, Czura CJ, Huston JM, Miller E, Lin X, Sherry B, Kumar A, Larosa G, Newman W, Tracey KJ and Yang H. (2006) Role of HMGB1 in apoptosis-mediated sepsis lethality. J Exp Med. 203: 1637-1642.

Wang H, Li W, Li J, Rendon-Mitchell B, Ochani M, Ashok M, Yang L, Yang H, Tracey KJ, Wang P and Sama AE. (2006) The aqueous extract of a popular herbal nutrient supplement, Angelica sinensis, protects mice against lethal endotoxemia and sepsis. J Nutr. 136: 360-365.

Chen G, Li J, Qiang X, Czura CJ, Ochani M, Ochani K, Ulloa L, Yang H, Tracey KJ, Wang P, Sama AE and Wang H. (2005) Suppression of HMGB1 release by stearoyl lysophosphatidylcholine:an additional mechanism for its therapeutic effects in experimental sepsis. J Lipid Res. 46: 623-627.

Cui X, Wu R, Zhou M, Dong W, Ulloa L, Yang H, Wang H, Tracey KJ, Simms HH and Wang P. (2005) Adrenomedullin and its binding protein attenuate the proinflammatory response after hemorrhage. Crit Care Med. 33: 391-398.

Chen G, Li J, Ochani M, Rendon-Mitchell B, Qiang X, Susarla S, Ulloa L, Yang H, Fan S, Goyert SM, Wang P, Tracey KJ, Sama AE and Wang H. (2004) Bacterial endotoxin stimulates macrophages to release HMGB1 partly through CD14- and TNF-dependent mechanisms. J Leukoc Biol. 76: 994-1001.

Wang H, Yang H and Tracey KJ. (2004) Extracellular role of HMGB1 in inflammation and sepsis. J Intern Med. 255: 320-331.

Wang H, Liao H, Ochani M, Justiniani M, Lin X, Yang L, Al Abed Y, Wang H, Metz C, Miller EJ, Tracey KJ and Ulloa L. (2004) Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis. Nat Med. 10: 1216-1221.

Wang H, Czura CJ and Tracey KJ. (2004) Lipid unites disparate syndromes of sepsis. Nat Med. 10: 124-125.

Yang H, Ochani M, Li J, Qiang X, Tanovic M, Harris HE, Susarla SM, Ulloa L, Wang H, DiRaimo R, Czura CJ, Wang H, Roth J, Warren HS, Fink MP, Fenton MJ, Andersson U and Tracey KJ. (2004) Reversing established sepsis with antagonists of endogenous high-mobility group box 1. Proc Natl Acad Sci U S A. 101: 296-301.

Rendon-Mitchell B, Ochani M, Li J, Han J, Wang H, Yang H, Susarla S, Czura C, Mitchell RA, Chen G, Sama AE, Tracey KJ and Wang H. (2003) IFN-gamma induces high mobility group box 1 protein release partly through a TNF-dependent mechanism. J Immunol. 170: 3890-3897.

Wang H, Yu M, Ochani M, Amella CA, Tanovic M, Susarla S, Li JH, Wang H, Yang H, Ulloa L, Al Abed Y, Czura CJ and Tracey KJ. (2003) Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Nature. 421: 384-388.

Wang H, Czura CJ and Tracey KJ. (2003) HMGB1. In: Thomson A and Lotze MT (eds) The Cytokine Handbook, pp 913-923. Academic Press, Oxford.

Wang H, Czura CJ and Tracey KJ. (2003) TNF. In: Thomson A and Lotze MT (eds) The Cytokine Handbook, pp 837-860. Academic Press, Oxford.

Wang H, Yang H, Czura CJ, Sama AE and Tracey KJ.  (2001). HMGB1 as a Late Mediator of Lethal Systemic Inflammation. Am J Respiratory and Crit Care Med. 164: 1768-1773.

Zhang M, Wang H and Tracey KJ. (2000) Regulation of macrophage activation and inflammation by spermine: a new chapter in an old story. Crit Care Med. 28: N60-N66.

Ombrellino M, Wang H, Ajemian MS, Talhouk A, Scher LA, Friedman SG and Tracey KJ. (1999) Increased serum concentrations of high-mobility-group protein 1 in haemorrhagic shock [letter]. Lancet. 354: 1446-1447.

Wang H and Tracey KJ. (1999) TNF, IL-6, MIF and MIP-1 in inflammation. In: Gallin JI and Snyderman R (eds) Inflammation: Basic Principles and Clinical Correlates, pp 471-486. Lippincott-Racen Press, Philadelphia.

Wang H, Bloom O, Zhang M, Vishnubhakat JM, Ombrellino M, Che J, Frazier A, Yang H, Ivanova S, Borovikova L, Manogue KR, Faist E, Abraham E, Andersson J, Andersson U, Molina PE, Abumrad NN, Sama A and Tracey KJ. (1999) HMG-1 as a late mediator of endotoxin lethality in mice. Science. 285: 248-251.

Ivanova S, Botchkina GI, Al-Abed Y, Meistrell M, Batliwalla F, Dubinsky JM, Iadecola C, Wang H, Gregersen PK, Eaton JW and Tracey KJ. (1998) Cerebral ischemia enhances polyamine oxidation: identification of enzymatically formed 3-aminopropanal as an endogenous mediator of neuronal and glial cell death. J Exp Med. 188: 327-340.

Wang H, Zhang M, Bianchi M, Sherry B, Sama A and Tracey KJ. (1998) Fetuin (alpha2-HS-glycoprotein) opsonizes cationic macrophagedeactivating molecules. Proc Natl Acad Sci U S A. 95: 14429-14434.

Wang H, Zhang M, Soda K, Sama A and Tracey KJ. (1997) Fetuin protects the fetus from TNF [letter]. Lancet. 350: 861-862.

Zhang M, Caragine T, Wang H, Cohen PS, Botchkina G, Soda K, Bianchi M, Ulrich P, Cerami A, Sherry B and Tracey KJ. (1997) Spermine inhibits proinflammatory cytokine synthesis in human mononuclear cells: a counterregulatory mechanism that restrains the immune response. J Exp Med. 185: 1759-1768.