Laboratory of Cognitive Neuroscience
Dr. Terry Goldberg is designing the next generation of neurocognitive assessments for patients with psychiatric disease. These tests will be used to diagnose and follow patients over time to see whether the treatments help in improving symptoms. The Feinstein Institute psychiatric researchers at The Zucker Hillside Hospital in Glen Oaks, NY, have led the way in studying first-episode schizophrenia patients and following them over time in an attempt to unravel the biology of the chronic disease process.
The studies conducted at the 223-bed psychiatric hospital have helped determine that the sooner a patient gets treatment, the better the outcome. Schizophrenia strikes one in every 100 people and the first symptoms generally appear in young adulthood. In a 2008 study in The Archives of General Psychiatry, Dr. Goldberg tested the widely-prescribed second-generation antipsychotic medications on their ability to strengthen cognitive processes damaged in schizophrenia.
He found out that the cognitive benefits touted by investigators and pharmaceutical companies are actually due to practice effects on the assessments designed to measure enhanced cognition, rather than an altering of the underlying disease process. More work is necessary to replicate Dr. Goldberg’s finding. He is also collaborating with Peter Gregersen, MD, and Peter Davies, PhD, on a study of cognitive aging. They will be looking for specific risk genes and asking patients to perform a series of cognitive tests to see how genes contribute to cognitive changes in old age.
Select Goldberg Publications:
Goldberg TE, Iudicello J, Elvevaag BE, Egan MF and Weinberger DR. BDNF val66met genotype is associated with memories, but not false memories. Biological Psychology 77:20-24, 2008.
Diaz-Asper CM, Goldberg TE, Kolachana BS, Richard E. Straub, Egan MF, and Weinberger DR. Genetic variation in Catechol-O-Methyltransferase (COMT): Effects on working memory function in schizophrenic patients and healthy controls. Biological Psychiatry 63: 72-79, 2008.
Straub RE, Lipska BK, Egan MF, Goldberg TE, Callicott JH, Mayhew MB, Vakkalanka RK, Kolachana BS, Kleinman JE, Weinberger DR.Allelic variation in GAD1 (GAD67) is associated with schizophrenia and influences cortical function and gene expression. Molecular Psychiatry 12:854-69, 2007.
Tan HY, Chen Q, Goldberg TE, Mattay VS, Meyer-Lindenberg A, Weinberger DR, Callicott JH.Catechol-O-methyltransferase Val158Met modulation of prefrontal-parietal-striatal brain systems during arithmetic and temporal transformations in working memory .Journal of Neuroscience 27:13393-401, 2007.
Buckholtz JW, Callicott JH, Kolachana B, Hariri AR, Goldberg TE, Genderson M, Egan MF, Mattay VS, Weinberger DR, Meyer-Lindenberg A.Genetic variation in MAOA modulates ventromedial prefrontal circuitry mediating individual differences in human personality. Molecular Psychiatry. 13:313-24, 2008.
Ceaser AE, Goldberg TE, Egan MF, McMahon RP, Weinberger DR, Gold JM. Set-shifting ability and schizophrenia: a marker of clinical illness or an intermediate phenotype? Biological Psychiatry. 2008; 64: 782-8.
de Geus E, Goldberg T, Boomsma DI, Posthuma D. Imaging the genetics of brain structure and function. Biological Psychology;79:1-8. 2008
Keefe RS, Harvey PD, Goldberg TE, Gold JM, Walker TM, Kennel C, Hawkins K. Norms and standardization of the Brief Assessment of Cognition in Schizophrenia (BACS).Schizophrenia Research 102:108-15, 2008.
Mattay VS, Goldberg TE, Sambataro F, Weinberger DR. Neurobiology of cognitive aging: Insights from imaging genetics. Biological Psychology 79:9-22, 2008.
Nuechterlein KH, Green MF, Kern RS, Baade LE, Barch DM, Cohen JD, Essock S, Fenton WS, Frese FJ 3rd, Gold JM, Goldberg T, Heaton RK, Keefe RS, Kraemer H, Mesholam-Gately R, Seidman LJ, Stover E, Weinberger DR, Young AS, Zalcman S, Marder SR.The MATRICS Consensus Cognitive Battery, part 1: test selection, reliability, and validity. American Journal of Psychiatry. 165:203-13, 2008.
Opgen-Rhein C, Lencz T, Burdick KE, Neuhaus AH, Goldberg TE, Malhotra AK. Genetic variation in the DAOA gene complex: Impact on susceptibility for schizophrenia and on cognitive performance. Schizophrenia Research 103:169-177, 2008.
Mattay VS, Goldberg TE, Sambataro F, Weinberger DR.Neurobiology of cognitive aging: insights from imaging genetics. Biological Psychology. 2008;79:9-22.
Huffaker SJ, Chen J, Nicodemus KK, Sambataro F, Yang F, Mattay V, Lipska BK, Hyde TM, Song J, Rujescu D, Giegling I, Mayilyan K, Proust MJ, Soghoyan A, Caforio G, Callicott JH, Bertolino A, Meyer-Lindenberg A, Chang J, Ji Y, Egan MF, Goldberg TE, Kleinman JE, Lu B, Weinberger DR. A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia. Nat Med. 2009; 15:509-18.
Murty VP, Sambataro F, Das S, Tan HY, Callicott JH, Goldberg TE, Meyer-Lindenberg A, Weinberger DR, Mattay VS. Age-related alterations in simple declarative memory and the effect of negative stimulus valence. Journal of Cognitive Neuroscience. Epub 2008 Sep 29.
Weickert TW, Goldberg TE, Callicott JH, Chen Q, Apud JA, Das S, Zoltick BJ, Egan MF, Meeter M, Myers C, Gluck MA, Weinberger DR, Mattay VS. Neural correlates of probabilistic category learning in patients with schizophrenia. Journal of Neuroscience 2009; 29:1244-54.
Goldberg TE, Burdick KE, McCormack J ,Napolitano B,. Patel RC, Goldman R, Lencz T, Malhotra AK, Kane JM, Robinson DG. Lack of an inverse relationship between duration of untreated psychosis and level of cognition in first episode schizophrenia. Schizophrenia Research. 2009;107:262-6.
Goldberg TE and Gomar J. Targeting cognition in schizophrenia research: From etiology to treatment. American Journal of Psychiatry (Editorial). 2009 166(6):631-634
Goldberg TE, Kotov R, Lee AT, Gregersen PK, Lencz T, Bromet E, Malhotra AK. The serotonin transporter gene and disease Modification in Psychosis: Evidence for systematic differences in allelic directionality at the 5-HTTLPR locus. Schizophrenia Research. 2009;111(1-3):103-8.
Koppel J, Bradshaw H, Goldberg TE, Khalili H, Marambaud P, Walker MJ, Pazos M, Gordon ML, Christen E, Davies P. Endocannabinoids in Alzheimer’s disease and their impact on normative cognitive performance. Lipids in Health and Disease 2009, 9. Epub ahead of print.
Leavitt VM, Goldberg TE. Episodic memory in schizophrenia. Neuropsychol Rev. 2009;19:312-23
Kuperberg GR, Ditman T, Kreher DA and Goldberg TE. The cognitive basis of language dysfunction in schizophrenia. In Handbook of Neuropsychology of Mental Illness, S Wood, N Allen and C Pantelis (Eds), Cambridge University Press. 2009
Meyer-Lindenberg A and Goldberg TE. Psychology and biology of memory. In New Oxford Textbook of Psychiatry 2nd Edition, MC Gelder, NC Andreasen, JJ Lopez-Ibor, JR Geddes, Oxford University Press, London. 2009.
Neuhaus AH, Goldberg TE, Hassoun Y, Bates JA, Nassauer KW, Sevy S, Opgen-Rhein C, Malhotra AK. Acute dopamine depletion with branched chain amino acids decreases auditory top-down event-related potentials in healthy subjects.Schizophrenia Research 2009 111(1-3):167-73.
Goldberg TE and Mattay VS. The genetics of cognitive aging. In Goldberg TE and Weinberger DR (Eds). Genetics of Cognitive Science. MIT Press, Boston, MA. In press.