Click here to view publications by Dr. Philippe Marambaud, PhD, in PubMed.

Vingtdeux V, Marambaud P. Letter to the Editor on "Involvement of AMP-activated-protein-kinase (AMPK) in neuronal amyloidogenesis". Biochem Biophys Res Commun. 2010 Sep 24;400(3):452.

Lambert JC, Sleegers K, González-Pérez A, Ingelsson M, Beecham GW, Hiltunen M, Combarros O, Bullido MJ, Brouwers N, Bettens K, Berr C, Pasquier F, Richard F, Dekosky ST, Hannequin D, Haines JL, Tognoni G, Fiévet N, Dartigues JF, Tzourio C, Engelborghs S, Arosio B, Coto E, De Deyn P, Del Zompo M, Mateo I, Boada M, Antunez C, Lopez-Arrieta J, Epelbaum J, Schjeide BM, Frank-Garcia A, Giedraitis V, Helisalmi S, Porcellini E, Pilotto A, Forti P, Ferri R, Delepine M, Zelenika D, Lathrop M, Scarpini E, Siciliano G, Solfrizzi V, Sorbi S, Spalletta G, Ravaglia G, Valdivieso F, Vepsäläinen S, Alvarez V, Bosco P, Mancuso M, Panza F, Nacmias B, Bossù P, Hanon O, Piccardi P, Annoni G, Mann D, Marambaud P, Seripa D, Galimberti D, Tanzi RE, Bertram L, Lendon C, Lannfelt L, Licastro F, Campion D, Pericak-Vance MA, Soininen H, Van Broeckhoven C, Alpérovitch A, Ruiz A, Kamboh MI, Amouyel P. The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study. J Alzheimers Dis. 2010;22(1):247-55.

Vingtdeux V, Chandakkar P, Zhao H, d'Abramo C, Davies P, Marambaud P. Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-beta peptide degradation. FASEB J. 2010 Sep 17. [Epub ahead of print]

Vingtdeux V, Davies P, Dickson DW, Marambaud P. AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer's disease and other tauopathies. Acta Neuropathol. 2010 Oct 19. [Epub ahead of print]

Vingtdeux V, Giliberto L, Zhao H, Chandakkar P, Wu Q, Simon JE, Janle EM, Lobo J, Ferruzzi MG, Davies P, Marambaud P. (2010) AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism. J Biol Chem. Mar 19;285(12):9100-13.

Marambaud P, Dreses-Werringloer U, Vingtdeux V. (2009) Calcium signaling in neurodegeneration. Mol Neurodegener. May 6;4:20.



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Koppel J, Bradshaw H, Goldberg TE, Khalili H, Marambaud P, Walker MJ, Pazos M, Gordon ML, Christen E, Davies P. (2009) Endocannabinoids in Alzheimer's disease and their impact on normative cognitive performance: a case-control and cohort study. Lipids Health Dis. Jan 14;8:2.

Vingtdeux V, Dreses-Werringloer U, Zhao H, Davies P, Marambaud P. (2008) Therapeutic potential of resveratrol in Alzheimer's disease. BMC Neurosci. Dec 3; 9 Suppl 2:S6.

Lambert JC, Campagne F, Marambaud P. (2008) CALHM1, a novel gene to blame in Alzheimer disease. Med Sci (Paris). Nov;24(11):923-924.

Campagne F, Lambert JC, Dreses-Werringloer U, Vingtdeux V, Lendon C, Campion D, Amouyel P, Lee AT, Gregersen PK, Davies P, Marambaud P. (2008) CALHM1 Association with Alzheimer’s Disease Risk. Cell. Dec 12; 135(6):994-6.

Dreses-Werringloer U, Lambert JC, Vingtdeux V, Zhao H, Vais H, Siebert A, Jain A, Koppel J, Rovelet-Lecrux A, Hannequin D, Pasquier F, Galimberti D, Scarpini E, Mann D, Lendon C, Campion D, Amouyel P, Davies P, Foskett JK, Campagne F, Marambaud P. (2008) A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk. Cell. Jun 27;133(7):1149-61.

Bacher M, Dodel R, Aljabari B, Keyvani K, Marambaud P, Kayed R, Glabe C, Goertz N, Hoppmann A, Sachser N, Klotsche J, Schnell S, Lewejohann L, Al-Abed Y. (2008) CNI-1493 inhibits Abeta production, plaque formation, and cognitive deterioration in an animal model of Alzheimer's disease. J Exp Med. Jul 7;205(7):1593-9.

Zhao H, Dreses-Werringloer U, Davies P, Marambaud P. (2008) Amyloid-beta peptide degradation in cell cultures by mycoplasma contaminants. BMC Res Notes. Jun 30;1:38.

Vingtdeux V, Hamdane M, Begard S, Loyens A, Delacourte A, Beauvillain JC, Buee L, Marambaud P, Sergeant N. (2007) Intracellular pH regulates amyloid precursor protein intracellular domain accumulation. Neurobiol Dis. 25(3): 686-96.

Chen F, Hasegawa H, Schmitt-Ulms G, Kawarai T, Bohm C, Katayama T, Gu Y, Sanjo N, Glista M, Rogaeva E, Wakutani Y, Pardossi-Piquard R, Ruan X, Tandon A, Checler F, Marambaud P, Hansen K, Westaway D, St George-Hyslop P, Fraser P. (2006) TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity. Nature. 440 (7088): 1208-12.

Agiostratidou G, Muros RM, Shioi J, Marambaud P, Robakis NK. (2006) The cytoplasmic sequence of E-cadherin promotes non-amyloidogenic degradation of Abeta precursors. J Neurochem. 96(4):1182-8.

Marambaud P, Zhao H, Davies P. (2005) Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides. J Biol Chem. 280: 37377-82.

Frederic C, Cristine Ada C, Erwan A, David A, Cecile D, Michael F, Jean-Fran Ois H, Martinez J, Solveig LJ, Marambaud P, Andrea P, Agnes P, Christopher P, Philippe R, Peter SG, Sherwin W. (2005) JLK Inhibitors: Isocoumarin Compounds as Putative Probes to Selectively Target the gamma-Secretase Pathway.
 Curr Alzheimer Res. 2:327-334.

d'Abramo C, Massone S, Zingg JM, Pizzuti A, Marambaud P, Dalla Piccola B, Azzi A, Marinari UM, Pronzato A, Ricciarelli R. (2005) Role of peroxisome proliferator-activated receptor gamma in amyloid precursor protein processing and amyloid beta-mediated cell death. Biochem J. 391: 693-8.

Marambaud P, Robakis NK. (2005) Genetic and Molecular Aspects of Alzheimer’s disease Shed Light on New Mechanisms of Transcriptional Regulation. Genes, Brain and Behavior. 4, 134-146.

Petit A, Pasini A, Alves da Costa C, Ayral E, Hernandez JF, Dumanchin-Njock C, Phiel CJ, Marambaud P, Wilk S, Farzan M, Fulcrand P, Martinez J, Andrau D, Checler F. (2003) JLK isocoumarin inhibitors: selective γ-secretase inhibitors that do not interfere with Notch pathway, in vitro and in vivo. J Neurosci Res. 74, 370-377.

Marambaud P, Wen PH, Dutt A, Shioi J, Takashima A, Siman R, Robakis NK. (2003) A CBP-binding transcriptional repressor produced by the PS1/e-cleavage of N-cadherin is inhibited by PS1 FAD mutations. Cell. 114, 635-645. (commentary by Rao and Finkbeiner, Cell 2003, 114: 533-535; and by Fortini M., Nature 2003, 425: 565-566).

Marambaud P, Shioi J, Serban G, Georgakopoulos A, Sarner S, Nagy V, Baki L, Wen P, Efthimiopoulos S, Shao Z, Wisniewski T, Robakis NK. (2002) A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions. EMBO J. Apr 15; 21(8):1948-56.

Marambaud P, Baki L, Efthimiopoulos S, Georgakopoulos A, Wen P, Cui W, Ozawa M, Friedrich Jr VL, Robakis NK. (2001) Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits epithelial cadherin/p120 association, and regulates stability and function of the cadherin adhesion complex. Proc Natl Acad Sci USA. Feb 27; 98(5):2381-6.

Checler F, Alves da Costa C, Ancolio K, Lopez-Perez Elvira, Marambaud P. (2000) Role of the proteasome in Alzheimer’s Disease. Biochim Biophys Acta. Jul 26;1502(1):133-8.

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Georgakopoulos A, Marambaud P, Friedrich VL Jr, Shioi J, Efthimiopoulos S, Robakis NK. (2000) Presenilin-1: a component of synaptic and endothelial adherens junctions. Ann N Y Acad Sci. 2000;920:209-14.

Georgakopoulos A, Marambaud P, Efthimiopoulos S, Shioi J, Cui W, Li D, Schutte M, Gordon R, Mehta P, Friedrich Jr VL, Robakis NK. (1999) Presenilin 1 is recruited to cell-cell contacts, forms complexes with the cadherin/catenin adhesion system and regulates cell-cell adhesion. Mol Cell. Dec;4(6):893-902.

Marambaud P, Ancolio K, Alves da Costa C, Checler F. (1999) Effect of protein kinase A inhibitors on the production of Abeta40 and Abeta42 by human cells expressing normal and Alzheimer's disease-linked mutated betaAPP and presenilin 1. Br J Pharmacol. Mar; 126(5):1186-90.

Marambaud P, Chevallier N, Ancolio K, Checler F. (1998) Post-transcriptional contribution of a cAMP-dependent pathway to the formation of alpha- and beta/gamma-secretases-derived products of beta APP maturation in human cells expressing wild-type and Swedish mutated beta APP. Mol Med. Nov; 4(11):715-23.

Marambaud P, Alves da Costa C, Ancolio K, Checler F. (1998) Alzheimer's disease-linked mutation of presenilin 2 (N141I-PS2) drastically lowers APPalpha secretion: control by the proteasome. Biochem Biophys Res Commun. Nov 9;252(1):134-8.

Marambaud P, Chevallier N, Lopez-Perez E, Drouot C, Vizzanova J, Fulcrand P, Martinez J, Wilk S, Checler F. (1998) Strategies for identification of secretases implicated in Alzheimer's disease. Ann Biol Clin (Paris). May-Jun; 56(3):277-84.

Marambaud P, Ancolio K, Lopez-Perez E, Checler F. (1998) Proteasome inhibitors prevent the degradation of familial Alzheimer's disease-linked presenilin 1 and potentiate A-beta 42 recovery from human cells. Mol Med. Mar; 4(3):147-57.

Marambaud P, Lopez-Perez E, Wilk S, Checler F. (1997) Constitutive and protein kinase C-regulated secretory cleavage of Alzheimer's beta-amyloid precursor protein: different control of early and late events by the proteasome. J Neurochem. Dec; 69(6):2500-5.

Ancolio K, Marambaud P, Dauch P, Checler F. (1997) Alpha-secretase-derived product of beta-amyloid precursor protein is decreased by presenilin 1 mutations linked to familial Alzheimer's disease. J Neurochem. Dec; 69(6):2494-9.

Barelli H, Lebeau A, Vizzavona J, Delaere P, Chevallier N, Drouot C, Marambaud P, Ancolio K, Buxbaum JD, Khorkova O, Heroux J, Sahasrabudhe S, Martinez J, Warter JM, Mohr M, Checler F. (1997) Characterization of new polyclonal antibodies specific for 40 and 42 amino acid-long amyloid beta peptides: their use to examine the cell biology of presenilins and the immunohistochemistry of sporadic Alzheimer's disease and cerebral amyloid angiopathy cases. Mol Med. Oct;3(10):695-707.

Marambaud P, Rieunier F, Wilk S, Martinez J, Checler F. (1997) Contribution of the proteasome to the alpha-secretase pathway in Alzheimer's disease. Adv Exp Med Biol. 421:267-72.

Chevallier N, Vizzavona J, Marambaud P, Baur CP, Spillantini M, Fulcrand P, Martinez J, Goedert M, Vincent JP, Checler F. (1997) Cathepsin D displays in vitro beta-secretase-like specificity. Brain Res. Mar 7; 750(1-2):11-9.

Marambaud P, Chevallier N, Barelli H, Wilk S, Checler F. (1997) Proteasome contributes to the alpha-secretase pathway of amyloid precursor protein in human cells. J Neurochem. Feb; 68(2):698-703.

Marambaud P, Wilk S, Checler F. (1996) Protein kinase A phosphorylation of the proteasome: a contribution to the alpha-secretase pathway in human cells. J Neurochem. Dec; 67(6):2616-9.

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