Click here to see publications by Kevin J Tracey, MD, in PubMed.

Waldburger JM, Boyle DL, Pavlov VA, Tracey KJ, Firestein GS. (2008) Acetylcholine regulation of synoviocyte cytokine expression by the alpha7 nicotinic receptor. Arthritis Rheum. 58(11): 3439-49. PMID: 18975306 [PubMed - indexed for MEDLINE]

Huston JM, Wang H, Ochani M, Ochani K, Rosas-Ballina M, Gallowitsch-Puerta M, Ashok M, Yang L, Tracey KJ, Yang H. (2008) Splenectomy protects against sepsis lethality and reduces serum HMGB1 levels. J Immunol. 181(5):3535-9. PMID: 18714026 [PubMed - indexed for MEDLINE]

Rosas-Ballina M, Ochani M, Parrish WR, Ochani K, Harris YT, Huston JM, Chavan S, Tracey KJ. (2008) Splenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia. Proc Natl Acad Sci U S A. 105(31): 11008-13. PMID: 18669662 [PubMed - indexed for MEDLINE]

Parrish WR, Rosas-Ballina M, Gallowitsch-Puerta M, Ochani M, Ochani K, Yang LH, Hudson L, Lin X, Patel N, Johnson SM, Chavan S, Goldstein RS, Czura CJ, Miller EJ, Al-Abed Y, Tracey KJ, Pavlov VA. (2008) Modulation of TNF release by choline requires alpha7 subunit nicotinic acetylcholine receptor-mediated signaling. Mol Med. 14(9-10): 567-74. PMID: 18584048 [PubMed - indexed for MEDLINE]

Huston JM, Gallowitsch-Puerta M, Ochani M, Ochani K, Yuan R, Rosas-Ballina M,  Ashok M, Goldstein RS, Chavan S, Pavlov VA, Metz CN, Yang H, Czura CJ, Wang H, Tracey KJ. (2007) Transcutaneous vagus nerve stimulation reduces serum high mobility group box 1 levels and improves survival in murine sepsis. Crit Care Med. 35(12): 2762-8. PMID: 17901837 [PubMed - indexed for MEDLINE]

Sloan RP, McCreath H, Tracey KJ, Sidney S, Liu K, Seeman T. (2007) RR interval variability is inversely related to inflammatory markers: the CARDIA study. Mol Med.  13(3-4): 178-84. PMID: 17592552 [PubMed - indexed for MEDLINE]

Tracey KJ. (2007) Physiology and immunology of the cholinergic antiinflammatory pathway. J Clin Invest. 117(2): 289-96. Review. PMID: 17273548 [PubMed - indexed for MEDLINE]

Qin S, Wang H, Yuan R, Li H, Ochani M, Ochani K, Rosas-Ballina M, Czura CJ, Huston JM, Miller E, Lin X, Sherry B, Kumar A, Larosa G, Newman W, Tracey KJ, Yang H. (2006) Role of HMGB1 in apoptosis-mediated sepsis lethality. J Exp Med. 203(7): 1637-42. PMID: 16818669 [PubMed - indexed for MEDLINE]

Huston JM, Ochani M, Rosas-Ballina M, Liao H, Ochani K, Pavlov VA, Gallowitsch-Puerta M, Ashok M, Czura CJ, Foxwell B, Tracey KJ, Ulloa L. (2006) Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis. J Exp Med. 203(7): 1623-8. PMID: 16785311 [PubMed - indexed for MEDLINE]
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Izuishi K, Tsung A, Jeyabalan G, Critchlow ND, Li J, Tracey KJ, Demarco RA, Lotze MT, Fink MP, Geller DA, Billiar TR. (2006) Cutting edge: high-mobility group box 1 preconditioning protects against liver ischemia-reperfusion injury. J Immunol. 176(12): 7154-8. PMID: 16751357 [PubMed - indexed for MEDLINE]

van Westerloo DJ, Giebelen IA, Florquin S, Bruno MJ, Larosa GJ, Ulloa L, Tracey KJ, van der Poll T. (2006) The vagus nerve and nicotinic receptors modulate experimental pancreatitis severity in mice. Gastroenterology. 130(6): 1822-30. PMID: 16697744 [PubMed - indexed for MEDLINE]

Pavlov VA, Ochani M, Gallowitsch-Puerta M, Ochani K, Huston JM, Czura CJ, Al-Abed Y, Tracey KJ. (2006) Central muscarinic cholinergic regulation of the systemic inflammatory response during endotoxemia. Proc Natl Acad Sci U S A. 103(13): 5219-23. PMID: 16549778 [PubMed - indexed for MEDLINE]

Tracey KJ.  (2005) Fat meets the cholinergic antiinflammatory pathway. J Exp Med. 202(8): 1017-21. Review. PMID: 16230472 [PubMed - indexed for MEDLINE]

Metz CN, Tracey KJ. (2005) It takes nerve to dampen inflammation. Nat Immunol. 6(8): 756-7. No abstract available. PMID: 16034431 [PubMed - indexed for MEDLINE]

Saeed RW, Varma S, Peng-Nemeroff T, Sherry B, Balakhaneh D, Huston J, Tracey  KJ, Al-Abed Y, Metz CN. (2005) Cholinergic stimulation blocks endothelial cell activation and leukocyte recruitment during inflammation. J Exp Med. 201(7): 1113-23. PMID: 15809354 [PubMed - indexed for MEDLINE]

Lotze MT, Tracey KJ. (2005) High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal. Nat Rev Immunol. 5(4): 331-42. Review. PMID: 15803152 [PubMed - indexed for MEDLINE]

Tsung A, Sahai R, Tanaka H, Nakao A, Fink MP, Lotze MT, Yang H, Li J, Tracey  KJ, Geller DA, Billiar TR. (2005) The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion. J Exp Med. 201(7): 1135-43. PMID: 15795240 [PubMed - indexed for MEDLINE]

Yang H, Wang H, Czura CJ, Tracey KJ. (2005) The cytokine activity of HMGB1. J Leukoc Biol. 78(1): 1-8. Review. PMID: 15734795 [PubMed - indexed for MEDLINE]

Wang H, Liao H, Ochani M, Justiniani M, Lin X, Yang L, Al-Abed Y, Wang H, Metz C, Miller EJ, Tracey KJ, Ulloa L. (2004) Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis. Nat Med. 10(11): 1216-21.  PMID: 15502843 [PubMed - indexed for MEDLINE]

Andersson U, Tracey KJ. (2004) HMGB1 as a mediator of necrosis-induced inflammation and a therapeutic target in arthritis. Rheum Dis Clin North Am. 30(3) :627-37, xi. Review. PMID: 15261345 [PubMed - indexed for MEDLINE]
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Czura CJ, Yang H, Amella CA, Tracey KJ. (2004) HMGB1 in the mmunology of sepsis (not septic shock) and arthritis. Adv Immunol. 004;84: 181-200. Review. No abstract available. PMID: 15246253 [PubMed - indexed for MEDLINE]

Tracey KJ, Warren HS. (2004) Human genetics: an inflammatory issue. Nature. 429(6987): 35-7. No abstract available. PMID: 15129268 [PubMed - indexed for MEDLINE]

Wang H, Yang H, Tracey KJ. (2004) Extracellular role of HMGB1 in inflammation and sepsis. J Intern Med. 255(3): 320-31. Review. PMID: 14871456 [PubMed - indexed for MEDLINE]

Andersson UG, Tracey KJ. (2004) HMGB1, a pro-inflammatory cytokine of clinical interest: introduction. J Intern Med. 255(3): 318-9. PMID: 14871455 [PubMed - indexed for MEDLINE]

Wang H, Czura CJ, Tracey KJ. (2004) Lipid unites disparate syndromes of sepsis. Nat Med. 10(2): 124-5. No abstract available. PMID: 14760415 [PubMed - indexed for MEDLINE]

Yang H, Ochani M, Li J, Qiang X, Tanovic M, Harris HE, Susarla SM, Ulloa L, Wang H, DiRaimo R, Czura CJ, Wang H, Roth J, Warren HS, Fink MP, Fenton MJ, Andersson U, Tracey KJ. (2003) Reversing established sepsis with antagonists of endogenous high-mobility group box 1. Proc Natl Acad Sci U S A. 101(1): 296-301. PMID: 14695889 [PubMed - indexed for MEDLINE]

Wang H, Yu M, Ochani M, Amella CA, Tanovic M, Susarla S, Li JH, Wang H, Yang H, Ulloa L, Al-Abed Y, Czura CJ, Tracey KJ. (2003) Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Nature. 421(6921): 384-8. PMID: 12508119 [PubMed - indexed for MEDLINE]

Tracey KJ. (2002) The inflammatory reflex. Nature. 420(6917): 853-9. Review.PMID: 12490958 [PubMed - indexed for MEDLINE]

Ulloa L, Ochani M, Yang H, Tanovic M, Halperin D, Yang R, Czura CJ, Fink MP,  Tracey KJ. (2002) Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation. Proc Natl Acad Sci U S A. (19): 12351-6. PMID: 12209006 [PubMed - indexed for MEDLINE]

Ivanova S, Batliwalla F, Mocco J, Kiss S, Huang J, Mack W, Coon A, Eaton JW,  Al-Abed Y, Gregersen PK, Shohami E, Connolly ES Jr, Tracey KJ. (2002) Neuroprotection in cerebral ischemia by neutralization of 3-aminopropanal. Proc Natl Acad Sci U S A. 99(8): 5579-84. PMID: 11943872 [PubMed - indexed for MEDLINE]

Bernik TR, Friedman SG, Ochani M, DiRaimo R, Ulloa L, Yang H, Sudan S, Czura  CJ, Ivanova SM, Tracey KJ. (2002) Pharmacological stimulation of the cholinergic antiinflammatory pathway. J Exp Med. 195(6): 781-8.PMID: 11901203 [PubMed - indexed for MEDLINE]

Abraham E, Arcaroli J, Carmody A, Wang H, Tracey KJ. (2000) HMG-1 as a mediator of acute lung inflammation. J Immunol. 165(6): 2950-4.PMID: 10975801 [PubMed - indexed for MEDLINE]

Andersson U, Wang H, Palmblad K, Aveberger AC, Bloom O, Erlandsson-Harris H, Janson A, Kokkola R, Zhang M, Yang H, Tracey KJ. (2000) High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes. J Exp Med. 192(4): 565-70.PMID: 10952726 [PubMed - indexed for MEDLINE]

Borovikova LV, Ivanova S, Zhang M, Yang H, Botchkina GI, Watkins LR, Wang H, Abumrad N, Eaton JW, Tracey KJ. (2000) Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature. 405(6785): 458-62.PMID: 10839541 [PubMed - indexed for MEDLINE]

Ombrellino M, Wang H, Ajemian MS, Talhouk A, Scher LA, Friedman SG, Tracey KJ. (1999) Increased serum concentrations of high-mobility-group protein 1 in haemorrhagic shock. Lancet. 354(9188): 1446-7.PMID: 10543678 [PubMed - indexed for MEDLINE]

Wang H, Bloom O, Zhang M, Vishnubhakat JM, Ombrellino M, Che J, Frazier A, Yang H, Ivanova S, Borovikova L, Manogue KR, Faist E, Abraham E, Andersson J, Andersson U, Molina PE, Abumrad NN, Sama A, Tracey KJ. (1999) HMG-1 as a late mediator of endotoxin lethality in mice. Science. 285(5425): 248-51.PMID: 10398600 [PubMed - indexed for MEDLINE]

Wang H, Zhang M, Bianchi M, Sherry B, Sama A, Tracey KJ. (1999) Fetuin (alpha2-HS-glycoprotein) opsonizes cationic acrophagedeactivating molecules. Proc Natl Acad Sci U S A. 95(24): 14429-34. PMID: 9826717 [PubMed - indexed for MEDLINE]

Ivanova S, Botchkina GI, Al-Abed Y, Meistrell M 3rd, Batliwalla F, Dubinsky JM, Iadecola C, Wang H, Gregersen PK, Eaton JW, Tracey KJ. (1998) Cerebral ischemia enhances polyamine oxidation: identification of enzymatically formed 3-aminopropanal as an endogenous mediator of neuronal and glial cell death. J Exp Med. 188(2): 327-40. PMID: 9670045 [PubMed - indexed for MEDLINE]

Tracey KJ. (1998) Suppression of TNF and other proinflammatory cytokines by the tetravalent guanylhydrazone CNI-1493. Prog Clin Biol Res. 397: 335-43. Review. No abstract available. PMID: 9575574 [PubMed - indexed for MEDLINE]

Wang H, Zhang M, Soda K, Sama A, Tracey KJ. (1997) Fetuin protects the fetus from TNF. Lancet. 350(9081):861-2. No abstract available. PMID: 9310607 [PubMed - indexed for MEDLINE]

Tracey KJ, Cerami A. (1994) Tumor necrosis factor: a pleiotropic cytokine and therapeutic target. Annu Rev Med. 45: 491-503. Review. PMID: 8198398 [PubMed - indexed for MEDLINE]

Bernhagen J, Calandra T, Mitchell RA, Martin SB, Tracey KJ, Voelter W, Manogue KR, Cerami A, Bucala R. (1993) MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia. Nature. 365(6448): 756-9. Erratum in: Nature 1995 378(6555):419. PMID: 8413654 [PubMed - indexed for MEDLINE]

Teng MN, Park BH, Koeppen HK, Tracey KJ, Fendly BM, Schreiber H. (1991) Long-term inhibition of tumor growth by tumor necrosis factor in the absence of cachexia or T-cell immunity. Proc Natl Acad Sci U S A. 88(9): 3535-9. PMID: 2023898 [PubMed - indexed for MEDLINE]

Fong Y, et al. (1989) Antibodies to cachectin/tumor necrosis factor reduce interleukin 1 beta and interleukin 6 appearance during lethal bacteremia. J Exp Med. 170(5): 1627-33. PMID: 2809510 [PubMed - indexed for MEDLINE]

Tracey KJ, et al. (1988) Cachectin/tumor necrosis factor induces cachexia, anemia, and inflammation. J Exp Med. 167(3):1211-27. PMID: 3351436 [PubMed - indexed for MEDLINE]

Tracey KJ, Fong Y, Hesse DG, Manogue KR, Lee AT, Kuo GC, Lowry SF, Cerami A.  (1987) Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia. Nature. 330(6149): 662-4. PMID: 3317066 [PubMed - indexed for MEDLINE]

Tracey KJ, et al. (1986) Shock and tissue injury induced by recombinant human cachectin. Science. 234(4775): 470-4. PMID: 3764421 [PubMed - indexed for MEDLINE]
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