Depression is a medical illness that is associated with a persistent feeling of sadness and loss of interest and it affects how a person feels, thinks and behaves. If untreated, depression can seriously impair daily functions and even lead to suicide. Depression is a chronic illness that usually requires long-term treatment. Although current treatments with medication and psychological counseling help most people afflicted by this disorder, depression tends to recur.

Feinstein Institute researchers are studying new approaches to treat depression, including the use of electroconvulsive therapy to prevent recurrences. They are also exploring ways to improve on the safety and effectiveness of delivery of electroconvulsive therapy.

Feinstein Institute investigators who study depression include George Petrides.