Molecular Genetics and Genomics

Course Leader

Peter Gregersen, MD

Academic Schedule

This one-semester course is held every three years in the fall/early winter semester (2016, 2019, etc.); meets weekly for 1.5 hrs.

Prerequisites

A previous course in genetics (undergraduate or graduate/medical school) is required.

Overall purpose/objective

This course for graduate students (physicians, physicians-in-training, scientists-in-training) will advance their knowledge of genetics and genomics. The topics covered include: chromosome and gene structure, concepts and methodologies in genetic analysis, discussion of simple vs. complex traits, use of animal models for genetic analysis, and new paradigms in genetics.

Class conduct

This class is taught through didactic lectures and incorporates journal club-style classes with class discussions.

After completion of the course, students will be able to:

  • Describe the structure and function of the human genome and how it is transmitted
  • Discuss how genome variation arises
  • Describe the contribution of genetics to functional variations between individuals and groups in susceptibility to and expression of various disorders
  • Differentiate between simple and complex traits
  • Describe current scientific and clinical applications of genomics
  • Perform simple quantitative genetic calculations and solve related problems
  • Evaluate various genetic and genomic technologies

Assessment

Attendance of course lectures and seminars by visiting scientists is mandatory.

Excused absences must be approved in advance.

Formative: Throughout the course, students will be assessed on problem-solving, quizzes, and in-class discussions

Summative: At the end of the course, students will be assessed through a final exam.

Final grades will be comprised of attendance (25%), participation (25%), quizzes/problem sets (25%), and final exam (25%). A minimum score of 80% is required to pass the course.

Readings

There is no textbook for this course. Readings will be provided by the Course Directors.