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The Feinstein Institute for Medical Research

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Nadeen Chahine, PhD

Director of the Bioengineering-Biomechanics Laboratory and Assistant Investigator,
The Feinstein Institute for Medical Research 

Assistant Professor of Molecular Medicine and Neurosurgery, Hofstra North Shore LIJ Health System

Phone: (516) 562-2574
Email: nchahine@nshs.edu

About the Investigator
Dr. Nadeen Chahine is an assistant investigator at the Feinstein Institute for Medical Research, assistant professor of Molecular Medicine and Neurosurgery, Hofstra North Shore LIJ Health System, and director of the Bioengineering-Biomechanics laboratory. She obtained her undergraduate degrees in Biomedical Engineering at Boston University (2000), and completed her PhD at Columbia University in the Musculoskeletal Biomechanics and Cellular Engineering laboratories under the direction of Dr. Gerard Ateshian and Dr. Clark Hung (2006).

After postdoctoral studies (2006-2008) at the Lawrence Livermore National Laboratory (Department of Energy) in micro/ nanotechnology as an Ernest Lawrence Fellow, Dr. Chahine developed a new bioengineering and biomechanics research program at the Feinstein Institute for Medical Research in New York.

Research Focus
Dr. Chahine’s research team focuses on degeneration and regeneration of musculoskeletal tissues, particularly intervertebral disc, articular cartilage and tendonous tissues. They use rigorous tools of bioengineering, cellular and molecular biology and animal physiology to characterize the function of healthy and diseased tissues. This approach is used to develop new treatment strategies for repairing arthritic and diseased musculoskeletal tissues using combinations of cells, biomaterials and chemical factors.

Her team’s research applies the tools of biomedical engineering to study and develop treatments for degenerate cartilaginous tissues in the musculoskeletal system. Specifically, their research is focused on the intervertebral disc in the spine, articular cartilage in the joints, and the Achilles tendon. These tissues play a pivotal role in load transmission during locomotion, and their ability to bear load changes with aging and degeneration.

The aim of Dr. Chahine’s research is two-fold: (1) Understand the role of inflammation in the etiology of injury and degeneration. (2) Design biological replacements of diseased cartilaginous tissues that can withstand the biomechanical and inflammatory environment after implantation. Her lab’s approach to this research utilizes hierarchical studies at the joint, tissue, cellular, and molecular level. The ultimate goal of studying the healthy function of tissues and cells is to develop treatments, and potentially cures, for degenerative diseases, such as disc disease and osteoarthritis.

Dr. Chahine’s lab hosts residents from the Departments of Neurosurgery and Orthopedic Surgery for research rotations. Dr. Chahine is an active member of the Bioengineering Division (BED) of the American Society for Mechanical Engineers (ASME) and Orthopaedic Research Society (ORS). She has successfully administered externally funded projects and collaborated with other internal and external researchers to produce several peer-reviewed publications. Dr. Chahine has a demonstrated record of early success and productive research projects in an area of high relevance to our aging population.

Lab Members
Chahine-Lab-photo-300wRobert Maidhof
PhD- Post Doctoral Trainee
Email: rmaidhof@nshs.edu
Phone: (516) 562-2534
Dr. Robert Maidhof obtained his undergraduate degree in Biomedical Engineering at Columbia University (2005), and completed his PhD at Columbia University in the Laboratory for Stem Cells and Tissue Engineering under the direction of Dr. Gordana Vunjak-Novakovic (2010). For his thesis, Dr. Maidhof worked in the field of cardiac tissue engineering developing novel combinations of bioreactors, biomaterials, and cells to grow functional cardiac tissue in vitro. Currently, Dr. Maidhof is working under the guidance of Dr. Chahine to engineer intervertebral disc tissues, create novel models of disc degeneration, and explore new treatment modalities using combinations of cells and biological molecules. Dr. Maidhof was selected for ‘Best Presentation’ award at the 2012 Philadelphia Spine Research Symposium.

Didier Olivier Alipui, MD
Post Doctoral Trainee / Clinical Fellow
Email: dalipui@nshs.edu
Phone: (516) 562-2541
Born and raised in Abidjan (Cote d’Ivoire), Olivier received his BS degree in Chemistry from City College of New York and MD degree from the University of Kansas. Olivier is currently a clinical Fellow at the Feinstein Institute for Medical Research, investigating biomarkers for degenerative disc disease and low back pain with Dr. Chahine and Dr. Levine. His interests include surgery and · trauma. He also enjoys Tae-kwondo, camping, soccer, running, cooking, ‘Family Guy’ and ‘Hell’s Kitchen’.

Asfi Rafiuddin, BS
Visiting Scientist
Email: arafuiddin@nshs.edu
Asfi is a third year medical student at New York College of Osteopathic Medicine. She received her BS degree through the accelerated BS/DO program at New York Institute of Technology. Her current research encompasses the development and in vivo tracking of cell based repair for intervertebral disc degeneration. Previously, she worked on juvenile epilepsy research examining mechanisms of seizure threshold and signaling pathways of protein kinase C in C-elegans.

Education
Boston University
Degree: BS
2000
Field of Study: Biomedical Engineering

Columbia University
Degree: MS
2002
Field of Study: Cell & Tissue Engineering

Columbia University
Degree: M. Phil.
2006
Field of Study: Biomechanics/Bioengineering

Columbia University
Degree: PhD
2006
Field of Study: Biomechanics/Bioengineering

Lawrence Livermore National Laboratory
Degree: Postdoc
2008
Field of Study: Micro & Nano Technology

Awards & Honors
1997 Student Leadership Award, Honored by Boston University Alumni
2000 Biomedical Engineering Graduate Research Assistantship (Columbia University)
2001 Annals of Biomedical Engineering Merit Award
2004 1st Place, Ph.D. Paper Competition, Bioengineering Division, Am. Society of Mechanical Engineering
2006 Leadership Development Forum, Bioengineering Div., Am. Soc. of Mechanical Eng., Amelia Island, FL
2006 Lawrence Post Doctoral Fellowship, Lawrence Livermore National Laboratory
2007 Leadership Development Forum, Bioengineering Div., Am. Soc. of Mechanical Eng., Keystone, CO
2007 National Academies Keck Futures Initiative on Aging, Newport, CA
2007 Feature Article, Nanotechnology Innovation; ‘Innovation’ Magazine, October/November
2011 Young Investigator Research Award Grant, The Feinstein Institute for Medical Research
2011 New Investigator Research Award Finalist, Orthopedic Research Society
2011 AOSpine Best Abstracts, Global Spine Congress, Barcelona, Spain
2012 National Science Foundation CAREER Award
2012 Jennifer & Bradley Marsh Early Career Development Award, Feinstein Institute for Medical Research
2013 Rising Star Award, Cellular and Molecular Bioengineering Conference, Biomedical Engineering Society
Publications
  1. Daher R.J., Chahine N.O., Greenberg A.S., Sgaglione N.A., Grande D.A., 2009, “The Second Generation of Diagnoses and Treatments of Cartilage Degeneration: A Review”, Nature Review Rheumatology, Volume 5, November 2009.
  2. Daher R.J., Chahine N.O., Razzano P, Patwa S.A., Sgaglione N.A., Grande D.A, 2011, “Tendon Repair Augmented With A Novel Circulating Stem Cell Population, International Journal of Clinical and Experimental Medicine.” 2011;4(3):214-219.
  3. Xu W, Chahine NO, Sulchek TA. 2011. “Extreme Hardening of PDMS Thin Films due to High Compressive Strain and Small Geometry.” Langmuir. 2011 Jul 5;27(13):8470-7.
  4. Ghorayeb SR, Shah N, Lozada L, Edobor-Osula F, Lane L, Razzano P, Chahine NO, Grande DA. 2012. “Ultrasonic Assessment of Collagen Content in Healing Achilles Tendon.” IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. 2012 Apr;59(4):694-702.
  5. Cummings S, Grande DA, Hee CK, Kestler HK, Roden CM, Razzano P, Dines DM, Chahine NO, Dines JS. 2012. “Effect of rhPDGF-BB-Coated Sutures on Tendon Healing in a Rat Model: A Histological and Biomechanical Study.” Journal of Tissue Engineering
  6. O’Connell G.D., Lima EG, Bian L, Chahine NO, Albro M, Cook JL, Ateshian GA, Hung CT, 2012. “Toward Engineering a Biological Joint Replacement.” Journal of Knee Surgery. Invited Review. In Press.
  7. Shah V, Bendele A, Kestler HK, Hollinger JO, Chahine NO, Hee CK. 2012. “Dose-Response Effect of an Intra-Tendon Application of Recombinant Human Platelet-Derived Growth Factor-BB (rhPDGF-BB) in a Rat Achilles Tendinopathy Model.” Journal of Orthopedic Research. In Press.
  8. Rajan N, Bloom O, Stetson N, Sherry B, Levine M, Chahine NO, 2012, “Toll-Like Receptor 4 Expression and Stimulation in a Model of Intervertebral Disc Inflammation and Degeneration.” Spine. In Press.
  9. Maidhof R, Alipui DA, Rafuiddin A, Levine M, Grande DA, Chahine NO, 2012, “Emerging Trends in Biological Therapy for Intervertebral Disc Disease. Discovery Health, Invited Review.” In Press.
  10. Chahine NO, Blanchette C, Thomas C, Lu J, Haudenschild G, Loots GG, 2012, “Effect of age and cytoskeletal elements on the indentation-dependent mechanical stiffness of chondrocytes.” PLOS One.

View more at PubMed