David Eidelberg, MD

Professor & Head, Feinstein Center for Neurosciences, The Feinstein Institute for Medical Research

Professor of Molecular Medicine and Neurology, Hofstra Northwell School of Medicine

Phone: (516) 562-2498
Email: david1@northwell.edu

About the Investigator

David Eidelberg, MD is internationally recognized for his pioneering work using functional brain networks as biomarkers of neurological disease. Using functional brain imaging, he and his research group have identified and characterized network biomarkers for degenerative brain disorders such as Parkinson’s disease, Huntington’s disease, Alzheimer’s disease, and frontotemporal dementia, as well as dystonia, tic disorder, and tremor. His work has led to validated network-based algorithms to aid in the diagnosis and management of patients with these disorders.

Dr. Eidelberg received his medical degree from Harvard Medical School. After completing residency training in neurology at Harvard, he pursued postdoctoral training in brain imaging with MRI (at The National Hospital, London UK) and PET (at Cornell in New York USA). He has led the Center for Neurosciences at The Feinstein Institute for Medical Research since its founding in 2001, serving as Director and Susan and Leonard Feinstein Professor of Neurology and Neuroscience. Dr. Eidelberg has received many grants and awards for his work from prominent research agencies including NIH and the Michael J. Fox Foundation. He is the author of over 350 peer-reviewed research articles, editorials, and reviews, as well as a textbook (Brain Imaging in Parkinson’s Disease, Oxford University Press 2011). Dr. Eidelberg serves on the editorial boards of several high-impact journals. He is a scientific advisor to the Michael J. Fox Foundation, the U.S. Department of Defense, and the COBRE Center for Neurodegeneration and Translational Neuroscience (CNTN).

Research Focus

Dr. Eidelberg directs a leading imaging research program in brain disease. His program is internationally recognized for developing novel imaging techniques to characterize and quantify neural circuits in neurodegenerative disorders and to study their modulation by using functional imaging with PET and fMRI.

Lab Members

Vijay Dhawan, PhD
Professor
Research: Dr. Dhawan’s research focuses on the use of novel radiotracers in functional brain imaging and studies the alterations in brain dopaminergic system that occurs in Parkinson’s disease and other movement disorders.
E-mail: vdhawan@northwell.edu

Andrew Feigin, MD
Associate Professor
Research: Dr. Feigin’s research focuses on using state-of-the-art positron emission tomography (PET) imaging methods to elucidate the mechanisms underlying current therapies for Parkinson’s disease and Huntington’s disease.
E-mail: afeigin@northwell.edu

Yilong Ma, PhD
Associate Professor
Research: Dr. Ma works on the development and application of brain imaging methodology in the study of neurodegenerative and neuropsychiatric disorders.
E-mail: yma@northwell.edu

Paul Mattis, PhD
Assistant Investigator
Research: Dr. Mattis’ research focuses on the neuropsychology of movement disorders, with special interest in the relationship between cognitive functioning and metabolism brain networks.
E-mail: pmattis@northwell.edu

Amir Nazem, MD, PhD
Research Scientist
Research: Dr. Nazem’s research focuses on biomarker discovery for early detection and differential diagnosis of dementia syndromes using metabolic brain networks.
E-mail: anazem@northwell.edu

Martin Niethammer, MD, PhD
Assistant Professor
Research: Dr. Niethammer’s research focuses on the use of neuroimaging in the investigation of Parkinson’s disease and Dystonia.
E-mail: mniethamme@northwell.edu

Shichun Peng, PhD
Research Scientist
Research: Dr. Peng’s research interests are in medical image processing and analysis with a focus on pattern recognition and multi-modality correlation.
E-mail: speng@northwell.edu

Phoebe Spetsieris, PhD
Associate Professor
Research: Dr. Spetsieris uses an integrated methodologies approach to develop a versatile PC based package (SCANVP) that has been widely used in multi-modal functional image data visualization and analysis.
E-mail: pspetsie@northwell.edu

Michael Small, MS
Research Assistant
Research: Michael Small’s research interests are in studying metabolic brain networks in Parkinson’s disease and related movement disorders.
E-mail: msmall3@northwell.edu

Chris Chengke Tang, MD, PhD
Assistant Investigator
Research: Dr. Tang research focuses on studying metabolic brain networks related to motor and cognitive abnormalities in neurodegenerative diseases.
E-mail: ctang@northwell.edu

An Vo, PhD
Assistant Professor
Research: Dr. Vo’s research interests are in functional magnetic resonance imaging (fMRI) processing and analysis of neurodegenerative disease.
E-mail: apo@northwell.edu

 

Postdoctoral Fellows

Koji Fujita, MD, PhD
Research: Dr. Fujita is a postdoctoral fellow who is investigating brain network abnormalities using fMRI, diffusion tensor imaging, and PET in movement disorders.
Email: kfujita@northwell.edu

Katharina Schindlbeck, MD
Research: Dr. Schindlbeck is a postdoctoral fellow who is studying disease-relevant pattern expressions in patients with specific genetic susceptibility factors.
Email: kschindl@northwell.edu

 

Administration

Yoon Young (Michelle) Choi, MS
Research Coordinator
Email: ychoi3@northwell.edu

Christine Edwards, MA
Administrative Director
E-mail: cedwards@northwell.edu

Toni Fitzpatrick, MS, CCRC
Research Coordinator
E-mail: tfitzpatrick@northwell.edu

Rosie Persaud
Administrative Assistant
E-mail: rpersaud@northwell.edu

Loreta Quartarolo, BS
Research Coordinator
E-mail: lquartar@northwell.edu

Education

Columbia University, New York, NY
Degree: BA
1977

Harvard Medical School, Boston, MA
Degree: MD
1981

Appointments

Susan and Leonard Feinstein Professor of Neurology and Neuroscience
Hofstra Northwell School of Medicine
Scientific Advisory Board, Michael J Fox Foundation for Parkinson’s Research
Scientific Advisory Board, Bachmann-Strauss Foundation for Dystonia & Parkinson’s Disease
Scientific Advisory Board, Dystonia Medical Research Foundation
Scientific Advisory Board, COBRE Center for Neurodegeneration and Translational Neuroscience (CNTN)

Publications
  1. Feigin A, Kaplitt MG, Tang C, Lin T, Mattis P, Dhawan V, During MJ, Eidelberg D (2007) “Modulation of metabolic brain networks following subthalamic gene therapy for Parkinson’s disease.” Proc Nat Acad Sci USA 104(49):19559-19564.
  2. Eidelberg D (2009) “Metabolic brain networks in neurodegenerative disorders: a functional imaging approach.” Trends Neurosci 32(10):548-557.
  3. Argyelan M, Carbon M, Niethammer M, Ulug AM, Henning UV, Bressman SB, Dhawan V, Eidelberg D (2009) “Cerebello-thalamo-cortical connectivity regulates penetrance in dystonia.” J Neurosci 29(31):9740-9747.
  4. Tang C, Poston K, Dhawan V, Eidelberg D (2010) “Abnormalities in metabolic network activity precede the onset of motor symptoms in Parkinson’s disease.” J Neurosci 30(3):1049-1056.
  5. Tang C, Poston K, Eckert T, Feigin A, Frucht S, Gudesblatt M, Dhawan V, Lesser M, Vonsattel J-P, Fahn S, Eidelberg D (2010) “Differential diagnosis of parkinsonism: a metabolic imaging study using pattern analysis.” Lancet Neurol 9(2):149-158.
  6. Ulug AM, Vo A, Argyelan M, Tanabe L, Schiffer WK, Dewey S, Dauer WT, Eidelberg D (2011) “Selective motor system abnormalities in DYT1 mutant TorsinA knock-in mice.” Proc Natl Acad Sci USA 108(16):6638-6643.
  7. Tang C, Feigin A, Ma Y, Habeck C, Paulsen JS, Teune LK, Leenders KL, Guttman M, Dhawan V, Eidelberg D (2013) “Metabolic network activity as a progression biomarker of premanifest Huntington’s disease.” J Clin Invest 123 (9): 4076-4088.
  8. Ko JH, Feigin A, Mattis PJ, Tang CC, Ma Y, Dhawan V, During MJ, Kaplitt MG, Eidelberg D (2014) “Network modulation following sham surgery in Parkinson’s disease.” J Clin Invest 124(8): 3656-3666.
  9. Spetsieris PG, Ko JH, Tang CC, Nazem A, Sako W, Peng S, Ma Y, Dhawan V, Eidelberg D (2015) “Metabolic resting state brain networks in health and disease.” Proc Nat Acad Sci USA, 112(8):2563-2568.
  10. Jourdain VA, Tang CC, Dresel C, Holtbernd F, Choi YY, Ma Y, Dhawan V, Eidelberg D (2016) “Flow-metabolism dissociation in the pathogenesis of levodopa-induced dyskinesia.” JCI Insight 1(15):e86615.

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