Jeffrey M. Lipton, MD, PhD

Head, Patient Oriented Research, The Feinstein Institute for Medical Research

Chief Hematology/Oncology and Stem Cell Transplantation,
Steven and Alexandra Cohen Children’s Medical Center of New York

Professor of Pediatrics and Molecular Medicine, Hofstra Northwell School of Medicine

Phone: (718) 470-3470
Email: jlipton@northwell.edu

About the Investigator

Jeffrey M. Lipton, MD, PhD, holds a BA from Queens College, City University of New York. He received a PhD in chemistry from Syracuse University and his medical degree magna cum laude from Saint Louis University Medical School. He did his pediatric training at the Children’s Hospital, Boston, MA, and his pediatric hematology/oncology fellowship training at the Children’s Hospital and the Dana Farber (formerly Sidney Farber) Cancer Institute in Boston.

As the president of the American Society of Pediatric Hematology Oncology (ASPHO) from 2010 to 2012, one of his priorities was the development of mentoring and career development opportunities for members. He also has mentored medical students and summer college students.

Dr. Lipton currently serves as a K08 advisor to Jason Farrar, MD, who has completed his fellowship at Johns Hopkins and is now assistant professor of pediatrics at the University of Arkansas. As an MD, PhD and principal investigator of an R01 supporting the Diamond Blackfan Anemia Registry, Dr. Lipton is responsible for directing translation research that relies upon robust communication between laboratory and clinical scientists.

Dr. Lipton is also the chief of hematology/oncology and stem cell transplantation at the Steven and Alexandra Cohen Children’s Medical Center of New York in New Hyde Park; the center head of patient oriented research at The Feinstein Institute for Medical Research; professor at Feinstein’s Elmezzi Graduate School of Molecular Medicine; and a professor of pediatrics and molecular medicine at Hofstra Northwell School of Medicine.

Dr. Lipton’s research interests focus on the rare inherited bone marrow failure syndromes. His current work is devoted to understanding the genetics, cellular and molecular biology of Diamond Blackfan anemia (DBA) and particularly malignant predisposition and birth defects observed in patients with DBA. He is the recipient of the 2010 Saint Louis University’s School of Medicine Alumni Merit Award and is an author of 175 original articles, reviews and book chapters.

Research Focus

The major goal of Dr. Lipton’s research is the elucidation of the genetics and pathophysiology of Diamond Blackfan anemia (DBA). During his career, he has attempted to translate laboratory knowledge into relevant diagnostic and therapeutic tools. The group he currently leads is working with numerous collaborators to develop meaningful genotype-phenotype correlations. This “group science” has led to the discovery of a number of DBA genotypes.

Through the Diamond Blackfan Anemia Registry (DBAR), opened in 1991, Dr. Lipton’s team has been able to provide a valuable substrate for laboratory investigations. In addition, they have developed mouse embryonic stem cell lines haploinsufficient for both rpl5 and rps19 that exhibit very different characteristics with regard to erythroid differentiation. In summary, the availability of animal models and a robust DBA database of well-characterized patients provide the cornerstone for advances in the diagnosis and treatment of DBA. Thus, translating knowledge from animal models to human disease is a natural progression of this work.

Dr. Lipton’s group has referred patients from the United States, Canada and abroad with undiagnosed bone marrow failure syndromes for diagnostic evaluation. Many of these patients remain undiagnosed and likely represent “new” disorders. Some of them have intermittent hematopoietic failure and are of great interest for Dr. Lionel Blanc’s studies.

Lab Members

Nelkin Laboratory:
Johnson Liu, MD
Investigator, Head

Abena Appiah-Kubi, MD
Research Fellow

Lionel Blanc, PhD
Assistant Investigator

Clinical Research Unit:
Adrianna Vlachos, MD
Associate Investigator, Head

Eva Atsidaftos, MA
Research Associate, CCRA

Ellen Muir, MSN
Research Nurse

Education

Queens College, City University of New York
Degree: BA
June 1967
Field of Study: Chemistry

Syracuse University, Syracuse New York
Degree: PhD
June 1972
Field of Study: Physical Chemistry

St. Louis University Medical School, St. Louis, MO
Degree: MD magna cum laude
June 1975
Field of Study: Medicine

Awards & Honors

1975-1976 Intern, Children’s Hospital Medical Center, Boston, MA
1976-1977 Junior Assistant Resident, Children’s Hospital Medical Center, Boston, MA
1977-1978 Research Fellow, Pediatric Hem/Onc, Children’s Hospital Medical Center, Boston, MA
1978-1979 Research Fellow in Pediatrics, Harvard Medical School, Boston, MA
1979-1981 Instructor in Pediatrics, Harvard Medical School, Boston, MA
1981-1984 Assistant Professor of Pediatrics, Harvard Medical School, Boston, MA
1984-1987 Associate Professor of Pediatrics, Columbia University, College of Physicians and Surgeons, New York, NY
1987-1999 Associate Professor of Pediatrics, Chief, Pediatric Hem/Onc, Mount Sinai School of Medicine, New York, NY
1997-1999 Associate Professor, The Derald H. Ruttenberg Cancer Center, Mount Sinai School of Medicine , NY,NY
1999-2001 Associate Professor of Pediatrics, Albert Einstein College of Medicine, New York, NY
1999-present Chief Pediatric, Hem/Onc and Stem Cell Transplantation, Schneider Children’s Hospital, New Hyde Park, NY
2001-2010 Professor of Pediatrics, Albert Einstein College of Medicine, NY
2007-present Center Head, Patient Oriented Research, The Feinstein Institute for Medical Research
2008-present Professor, Elmezzi Graduate School of Molecular Medicine, The Feinstein Institute for Medical Research, Manhasset, NY
2010-present Professor of Pediatrics and Molecular Medicine, Hofstra Northwell School of Medicine

Publications
  1. Lipton JM, Kudisch M, Gross R, and Nathan DG: “Defective erythroid progenitor differentiation system in congenital hypoplastic (Diamond Blackfan) anemia.” Blood 67: 962-968, 1986.
  2. Tsai PH, Arkin S, and Lipton JM: “An intrinsic progenitor defect in Diamond Blackfan anemia.” Brit J Haematol 73: 112-120, 1989.
  3. Arkin S, Naprstek B, Guarini L, Ferrone S, Lipton JM: “Expression of ICAM-1 (CD 54) on hematopoietic progenitors.” Blood 77: 1-6, 1991.
  4. Alter, BP, Gaston, T, Lipton JM: “Lack of effect of corticosteroids W/Wv and SL/SLd mice: These strains are not a model for steroid-responsive Diamond-Blackfan anemia.” Eur J Haematol 50:275-278, 1993.
  5. Gillio, AP, Faulkner, LB, Alter, BP, Reilly, L, Klafter, R, Heller, G, Young, DC, Lipton JM, Moore, MAS, O’Reilly, RJ: “Treatment of Diamond-Blackfan Anemia with recombinant human interleukin-3.” Blood 82: 744-751, 1993.
  6. Perdahl EB, Naprstek BL, Wallace WC, Lipton JM: “Erythroid failure in Diamond-Blackfan Anemia is characterized by apoptosis.” Blood 83: 645-650, 1994.
  7. Lipton JM, Federman N, Khabbaze Y, Schwartz CL, Hilliard LM, Clark JI, Vlachos A: “Osteogenic sarcoma associated with Diamond Blackfan anemia: A report from the Diamond Blackfan Anemia Registry.” J Pediatr Hematol/Oncol 23: 39-44, 2001.
  8. Vlachos A, Federman N, Reyes-Haley C, Abramson J, Lipton JM: “Hematopoietic stem cell transplantation for Diamond Blackfan anemia: A report from the Diamond Blackfan Anemia Registry.” Bone Marrow Transplant 27: 381-386, 2001.
  9. Gazda H, Lipton JM, Willig T-N, Ball S, Niemeyer CM, Tchernia G, Mohandas N, Daly MJ, Ploszynska A, Orfali KA, Vlachos A, Glader BE, Rokicka-Milewska R, Ohara A, Baker D, Pospisilova D, Webber A, Viskochil DH, Nathan DG, Beggs AH, Sieff CA: “Evidence for linkage of familial Diamond-Blackfan anemia to chromosome 8p23.3-p22 and for non-19q non-8p disease.” Blood 97: 2145-2150, 2001.
  10. Gripp KW, McDonald-McGinn DM, La Rossa D, McGain D, Federman N, Vlachos A, Glader BE, McKenzie SE, Lipton JM, Zackai EH: “Bilateral microtia and cleft palate in cousins with Diamond-Blackfan anemia.” Am J Med Genet 101: 268-274, 2001.

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