Investigator, The Feinstein Institute for Medical Research
Associate Professor, Molecular Medicine, Hofstra Northwell School of Medicine
Phone: (516) 562-1591
Dr. Ojamaa is an associate investigator for the Lab for Molecular Cardiovascular Research at the Feinstein Institute for Medical Research and an associate professor of Molecular Medicine at Hofstra Northwell School of Medicine and Pediaric Cardiology at Steven & Alexandra Cohen Medical Center.
Dr. Ojamaa’s laboratory has been studying cardiac growth regulation, intracellular signaling and gene expression, and has focused recently on the role of innate immunity and inflammatory responses in heart and lung in response to infections and ischemia/hypoxia. This research effort grew from a working collaboration with several investigators at the Feinstein Institute whose expertise in inflammation, endothelial reactivity, autoimmunity, have added immeasurably to the studies centered on the ischemic heart as well as cardiac hypertrophy and failure.
Dr. Ojamaa’s laboratory focuses on understanding the causes of heart disease in both the young and the adult patient with the goal of developing novel therapeutics for these disorders. Specifically, their studies address the role of inflammation and neuro-hormones in the response of the heart to the damaging effects of myocardial ischemia during a heart attack, and why the heart often fails in the long term. In the newborn patient, they aim to understand how increased inflammation may affect neurodevelopment.
One in five Americans over age 40 will develop heart failure resulting in a poor quality of life and increased mortality, which comes with an increased cost to society. Pathologic growth of the human heart is a clinical diagnosis defined by an increase in the mass of the heart that is an important risk factor for increased mortality. The lab’s research focuses on potential targets for therapeutics in this complex disease such as anti-oxidants and hormones (thyroid hormones) that are naturally present in the heart and circulation. Their experimental preclinical studies have found that these molecules can reduce oxidative stress within the hypertrophied heart leading to improved function and overall survival.
Coronary artery disease is the primary cause of heart disease in the US with more than one million people experiencing a heart attack each year. Although non-invasive intervention such as catheterization or coronary artery bypass graft surgery has saved lives, many survivors go on to develop heart failure and arrhythmias with a diminished quality of life. The lab is studying ways to minimize damage to the heart tissue after an ischemic event by targeting cellular repair and survival mechanisms, thereby improving cardiac tissue remodeling and contractile function. Specifically, targeting the inflammatory responses after cardiac ischemia may improve cardiac function and long term heart health.
Congenital heart disease affects one in 120 live births. Surgical correction of the heart defect often occurs within the particularly vulnerable newborn period within one month of life. The lab is studying the effects of inflammation and immune mechanisms on the brain and neurocognitive development of these neonates, and specifically, the effects of surgically-induced inflammation on the brain, heart and lung functions. Their studies aim to find ways to lessen the damaging effects of inflammatory molecules and to reduce innate immune activation so that the brain can be protected.
Postdoctoral research trainee
Hofstra Northwell School of Medicine MD/PhD student
Lindsey McPhillips, DO
Pediatric Cardiology fellow
McGill University, Canada
Field of Study: Biochemistry
McGill University, Canada
Field of Study: Biochemistry
Pennsylvania State University, PA
Field of Study: Physiology
1970-1975 JW McConnell Memorial Scholarship; and Margaret E. Wilson Bursary; and J. Lellepi Scholarship at McGill University
1977-1979 Walter M. Stewart Postgraduate Scholarship at McGill University
1979-1985 Post-graduate Stipend at Pennsylvania State University
1985-1987 NIH Fogarty Fellowship
1994-1998 American Heart Association – NY State Affiliate peer review cmte. member
1997 American Heart Association – Award for Excellence in Cardiovascular Research
1998-2003 Independent Scientist Award, National Heart, Lung and Blood Institute, NIH
1998-2002 NIH Cardiovascular A Study Section regular member
1999-2000 American Heart Association – NE Consortium peer review cmte chairperson
2005 NIH Cardiac Contractility, Hypertrophy & Failure Study Section, Ad Hoc reviewer
2005 NIH MABS (Modeling & Analysis of Biological Systems) study section, Ad Hoc reviewer
2005 Philip Morris External Research Program, Ad Hoc reviewer
2002-2006 AHA-Heritage Research Cmte. Co-chairperson
2006 AHA NE consortium peer review cmte member
2007 AHA Heritage
2008 peer review cmte Chairperson, Clinically Applied Research Applications AHA National peer review cmte member
2010 NIH Cardiac Contractility, Hypertrophy & Heart Failure study section, Ad Hoc reviewer
2011 NIH Cardiovascular Sciences, Ad Hoc reviewer
2011 American Heart Association – Rock Star of Research Recognition Award
2012 Robin & Jack Ross Faculty Mentorship Award
2014 Dvora Horvitz Segal Memorial Research-in-Training Award
2015 Meadowbrook Initiative Grant for Educational Advancement