Kim R. Simpfendorfer, PhD

Institute Scientist, Center for Genomics and Human Genetics,
The Feinstein Institute for Medical Research

Phone: (516) 562-2952

About the Investigator

Dr. Kim Simpfendorfer completed her undergraduate degrees and PhD at the University of Melbourne in the Department of Microbiology and Immunology, in Melbourne Australia. Her PhD studies focused on the mucosal immune system and particularly on the presence of antibodies that function to protect the body’s mucosal surfaces. She also studied secreted mucosal antibodies in the context of interactions between the environment and the development of autoimmune diseases such as Type 1 Diabetes.

Kim joined Center for Genomics and Human genetics in 2010 as a Postdoctoral Fellow to work with Dr. Peter K. Gregersen on the functional genetics of human autoimmunity. Kim served as the Secretary of the Young Investigators Society at the Feinstein Institute from August 2014 until September 2015.

Research Focus

Since joining Dr Peter Gregersen’s group at The Feinstein Institute for Medical Research, Kim’s research has focused on the functional analysis of immune-related genes associated with lupus and rheumatoid arthritis.


The Feinstein Institute for Medical research, Manhasset, NY
Degree: Postdoc
Field of Study: Genetics of Human Autoimmunity

The University of Melbourne, Victoria, Australia
Degree: PhD
Field of Study: Microbiology and Immunology

  1. Simpfendorfer KR, Armstead BE, Shih A, Li W, Curran M, Manjarrez-Orduño N, Lee AT, Diamond B, Gregersen PK. 2015. “Autoimmune disease associated haplotypes of BLK exhibit lowered thresholds for B-cell activation and expansion of immunoglobulin class switched B-cells.” Arthritis Rheumatol. doi: 10.1002/art.39301.
  2. Simpfendorfer KR, Strugnell RA, Brodnicki TC, Wijburg OLC. 2015. “Increased Autoimmune Diabetes in pIgR-Deficient NOD Mice Is Due to a ‘Hitchhiking’ Interval that Refines the Genetic Effect of Idd5.4” PlosOne 10: e0121979
  3. Simpfendorfer KR, Olsson LM, Manjarrez Orduno N, Khalili H, Simeone AM, Katz MS, Lee AT, Diamond B, Gregersen PK. 2012. “The autoimmunity-associated BLK haplotype exhibits cis-regulatory effects on mRNA and protein expression that are prominently observed in B cells early in development.” Hum Mol Genet 21: 3918-25
  4. Manjarrez-Orduno N, Marasco E, Chung SA, Katz MS, Kiridly JF, Simpfendorfer KR, Freudenberg J, Ballard DH, Nashi E, Hopkins TJ, Cunninghame Graham DS, Lee AT, Coenen MJ, Franke B, Swinkels DW, Graham RR, Kimberly RP, Gaffney PM, Vyse TJ, Behrens TW, Criswell LA, Diamond B, Gregersen PK. 2012. “CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation.” Nat Genet 44: 1227-30
  5. Gregersen PK, Kosoy R, Lee AT, Lamb J, Sussman J, McKee D, Simpfendorfer KR, Pirskanen-Matell R, Piehl F, Pan-Hammarstrom Q, Verschuuren JJ, Titulaer MJ, Niks EH, Marx A, Strobel P, Tackenberg B, Putz M, Maniaol A, Elsais A, Tallaksen C, Harbo HF, Lie BA, Raychaudhuri S, de Bakker PI, Melms A, Garchon HJ, Willcox N, Hammarstrom L, Seldin MF. 2012. “Risk for myasthenia gravis maps to a (151) Pro–>Ala change in TNIP1 and to human leukocyte antigen-B*08.” Ann Neurol 72: 927-35
  6. Becher D, Deutscher ME, Simpfendorfer KR, Wijburg OL, Pederson JS, Lew AM, Strugnell RA, Walduck AK. 2010. “Local recall responses in the stomach involving reduced regulation and expanded help mediate vaccine-induced protection against Helicobacter pylori in mice.” Eur J Immunol 40: 2778-90
  7. Achard ME, Tree JJ, Holden JA, Simpfendorfer KR, Wijburg OL, Strugnell RA, Schembri MA, Sweet MJ, Jennings MP, McEwan AG. 2010. “The multi-copper-ion oxidase CueO of Salmonella enterica serovar Typhimurium is required for systemic virulence.” Infection & Immunity 78: 2312-9
  8. Sait LC, Galic M, Price JD, Simpfendorfer KR, Diavatopoulos DA, Uren TK, Janssen PH, Wijburg OL, Strugnell RA. 2007. “Secretory antibodies reduce systemic antibody responses against the gastrointestinal commensal flora.” Int Immunol 19: 257-65
  9. Price JD, Simpfendorfer KR, Mantena RR, Holden J, Heath WR, van Rooijen N, Strugnell RA, Wijburg OL. 2007. “Gamma interferon-independent effects of interleukin-12 on immunity to Salmonella enterica serovar Typhimurium.” Infection & Immunity 75: 5753-62
  10. Wijburg OL, Uren TK, Simpfendorfer K, Johansen FE, Brandtzaeg P, Strugnell RA. 2006. “Innate secretory antibodies protect against natural Salmonella typhimurium infection.” J Exp Med 203: 21-6
  11. Chen Z, de Kauwe AL, Keech C, Wijburg O, Simpfendorfer K, Alexander WS, McCluskey J. 2006. “Humanized transgenic mice expressing HLA DR4-DQ3 haplotype: reconstitution of phenotype and HLA-restricted T-cell responses.” Tissue Antigens 68: 210-9

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