Lance B. Becker, MD, FAHA

Investigator, The Feinstein Institute for Medical Research

Chair, Emergency Medicine, Northwell Health

Professor and Chair, Emergency Medicine, Hofstra Northwell School of Medicine

Phone: (516) 562-3970
Email: lance.becker@northwell.edu

About the Investigator

Lance Becker, MD, FAHA is an investigator at the Feinstein Institute and serves as the chair and professor of emergency medicine at the Hofstra Northwell School of Medicine, and chair of the emergency departments at North Shore University Hospital and Long Island Jewish Medical Center. He is an internationally-recognized leader in the field of resuscitation, cardiac arrest, and critical care. His most impactful publications focused on question like “where are the survivors (from cardiac arrest)”, creating the Utstein international nomenclature for resuscitation, the original description of the three-phase model of cardiac arrest, reporting disparities in rates of cardiac arrest for minority populations, reappraisal of mouth-to-mouth ventilation, the instillation of AED’s in public settings, ischemia/reperfusion physiology, mitochondrial and metabolic approaches to resuscitation, and the critical descriptions of real-time quality of CPR measures during human cardiac arrest.

At the national level, Dr. Becker has publically advocated for NIH funding for resuscitation research as a leader of the PULSE Initiative that created multiple RFAs totaling over 150M dollars toward research in the last decade. He co-founded and chaired the American Heart Association’s Resuscitation Science Symposium which is the leading international venue for presentation of cutting edge resuscitation science, has served as chair of the AHA’s Peer Review subcommittee, chair of the Basic Life Support Committee, chair of the Cardiopulmonary, Perioperative, and Resuscitation Council, and helped establish the International Liaison Committee on Resuscitation (ILCOR) now responsible for the worlds recommendations on resuscitation practices. Dr. Becker is an elected member of the Institute of Medicine and National Academy of Medicine (IOM/NAM) has been a leader within the IOM/NAM efforts to improve survival from cardiac arrest and helped write the recent report “Strategies to Improve Survival from Cardiac Arrest: A Time to Act” and is currently working to develop a national Collaborative to improve survival from cardiac arrest.

Research Focus

Dr. Becker’s research focuses on the acute resuscitation of dying and critically sick patients. The Feinstein Lab group has developed several advanced animal models of critical illness and cardiac arrest. These experimental models are used to develop new treatments, new advanced biosensors, and to increase our understanding of ischemia/reperfusion physiology.

The laboratory has experience and expertise with the measurements of mitochondrial dysfunction, reactive oxygen and nitrogen species responses to ischemia, apoptotic activation following ischemia, signaling pathways, acute changes in lipid biochemistry following ischemia, changes in oxygen metabolism after ischemia, new cellular cytoprotective strategies and hypothermia protection strategies such as intra-arrest cooling. A unique aspect of the lab is an emphasis on bioengineering; this engineering perspective has been used to better understand the mechanisms of blood flow during CPR, and in using tissue auto-florescence as a measure of redox conditions within the cell and within tissues.

A current focus of his lab at the Feinstein Institute is on developing emergency cardiopulmonary bypass coupled with advanced drugs to save lives of patients who fail traditional advanced cardiovascular life support (ACLS) treatment. An advanced animal model of emergency cardiopulmonary bypass has been developed to resuscitate animals following very prolonged periods of cardiac arrest. Experiments with multiple drugs targeted at reperfusion injury have been incorporated to improve neurological function for surviving animals, and a combination of drugs is currently under investigation for possible clinical use in the future.

A recent direction of the lab is to better define changes in oxygen consumption during resuscitation. The laboratory is trying to discern whether or not alterations in carbon metabolism and consumption of oxygen may signal the need for a new paradigm of alternative treatments in critically ill patients.

Lab Members

Joshua Lampe
Email: jlampe@northwell.edu

Koichiro Shinozaki
Email: kshinozaki@northwell.edu

Junhwan Kim
Email: jkim46@northwell.edu

Tai Yin
Email: tyin@northwell.edu

Education

University of Illinois College of Medicine
Degree: MD
1981

University of Illinois
1977
Field of Study: Biochemistry of Graduate Studies

University of Michigan
Degree: BGS
1975

Honors and Awards

2015 Selected as the 2015 Recipient of the “Asmund S. Laerdal Lecture Award” from the Society of Critical Care Medicine’s Critical Care Congress, Phoenix, Arizona
2014 “Outstanding Contribution in Research” 2014 Award at the American College of Emergency Physicians Annual Meeting, Chicago, IL
2013 Karolinska Institute, Sweden – Elected for The Annual Clinical Science Lecture
2012 Elected to Lifetime Honorary Member, the European Resuscitation Council (ERC) Scientific Congress, Vienna
2012 “Lifetime Achievement Award in Cardiac Resuscitation Science” honored at the American Heart Association’s Resuscitation Science Symposium’s Annual Meeting in Los Angeles, CA
2012 “Hans H. Dahll” Award from the Emergency Cardiovascular Care Citizen CPR Foundation in Orlando, FL
2010 “Giant of Resuscitation” Award from the American Heart, Association’s International Liaison Committee on Resuscitation (ILCOR)
2008 Chairman’s Award of the American Heart Association, honored at the Scientific Sessions’ Annual Meeting in New Orleans, LA
2008 Negovsky Lecture, The European Resuscitation Council 9th European Congress in Ghent, Belgium
2008 Award of Meritorious Achievement, American Heart Association, for co-Founding of the Resuscitation Science Symposium, honored Washington, DC
2007 Elected to the Institute of Medicine, National Academy of Sciences, Washington, DC
2003 Inaugural Fellow, American Heart Association
2003 Dickinson W. Richards Lecturer, American Heart Association Scientific Sessions, Orlando, FL
2001 Asmund Laerdal Award, Scandinavian Society of Anesthesia and Intensive Care, Tromso, Norway
1997 Attending of the Year, Emergency Medicine Housestaff University of Chicago
1981 Honors upon graduation, University of Illinois College of Medicine
1980 Alpha Omega Alpha selected as junior student, University of Illinois College of Medicine

Publications
  1. Sutton RM, Friess SH, Maltese MR, Naim MY, Bratinov G, Weiland TR, Garuccio M, Bhalala U, Nadkarni VM, Becker LB, Berg RA. “Hemodynamic-directed cardiopulmonary resuscitation during in-hospital cardiac arrest.” Resuscitation. Apr 28, 2014.
  2. Friess SH, Sutton RM, French B, Bhalala U, Maltese MR, Naim MY, Bratinov G, Rodriguez SA, Weiland TR, Garuccio M, Nadkarni VM, Becker LB, Berg RA. “Hemodynamic Directed CPR Improves Cerebral Perfusion Pressure and Brain Tissue Oxygenation.” Resuscitation. June 16, 2014.
  3. Kim J, Yin T, Ming Y, Zhang W, Shinozaki K, Selak MA, Pappan KL, Lampe JW, Becker LB. “Examination of Physiological Function and Biochemical Disorders in a Rat Model of Prolonged Asphyxia-Inducted Cardiac Arrest followed by Cardio Pulmonary Bypass Resuscitation”. PLOS ONE. 2014 Nov 10;9(11):e112012
  4. Sutton RM, Friess SH, Naim MY, Lampe JW, Bratinov G. Weiland TR 3rd, Garuccio M, Nadkarni VM, Becker LB, Berg RA. “Patient-centric blood pressure-targeted cardiopulmonary resuscitation improves survival from cardiac arrest”. Am J Respir Crit Care Med. December 1, 2014; 190(11):1255-62.
  5. Wang H, Guan Y, Widlund AL, Becker LB, Baur JA, Reilly PM, Sims CA. “Resveratrol ameliorates mitochondrial dysfunction but increases the risk of hypoglycemia following hemorrhagic shock”. J Trauma Acute Care Surg. December, 2014; 77(6):926-33.
  6. Weiss SL, Selak MA, Tuluc F. Perales Villarroel J, Nadkarni VM, Deutschman CS, Becker LB. “Mitochondrial dysfunction in peripheral blood mononuclear cells in pediatric septic shock”. Pediatr Crit Care Med. January, 2015; 16(1).
  7. Shinozaki K, Lampe JW, Wang CH, Yin T, Kim J, Oda S, Hirasawa H, Becker LB. “Developing dual hemofiltration plus cardiopulmonary bypass in rodents”. J Surg Res. 2015 May 1;195(1):196-203.
  8. Patil KD, Halperin HR, Becker LB. “Cardiac Arrest: resuscitation and reperfusion”. Circ Res. June 5, 2015; 116(12):2041-9.
  9. Yannopoulos D, Aufderheide TP, Abella BS, Duval S, Franscone RJ, Goodloe JM, Mahoney BD, Nadkarni VM, Halperin HR, O’Connor R, Idris AH, Becker LB, Pepe PE. “Quality of CPR: An important effect modifier in cardiac arrest clinical outcomes and intervention effectiveness trials”. Resuscitation. June, 2015
  10. Kim J, Lampe JW, Yin T, Shinozaki K, Becker LB “Phospholipid alterations in the brain and heart in a rat model of asphyxia-induced cardiac arrest and cardiopulmonary bypass resuscitation”. Mol Cell Biochem. Jul 17, 2015; DOI: 10.1007/s11010-015-2505-0

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