Leonid Poretsky, MD

Chief, Division of Endocrinology, Lenox Hill Hospital, Northwell Health

Professor of Medicine, Hofstra Northwell School of Medicine

Phone: (212) 434-3662
Email: lporetsky@northwell.edu

About the Investigator

Dr. Leonid Poretsky graduated from First (Pavlov) Medical Institute in Leningrad, Russia (now St. Petersburg State Medical University), cum laude in 1977. He completed a fellowship in endocrinology and metabolism at Boston’s Beth Israel Hospital (now Beth Israel/Deaconess Medical Center) and a research fellowship at Harvard Medical School (1983–1985). He is professor of medicine at Hofstra Northwell School of Medicine and Chief of the Division of Endocrinology at Lenox Hill Hospital in New York City, a member of the Northwell Health System. His research interests include mechanisms of insulin action in the ovary, endocrinological aspects of AIDS and clinical outcomes in diabetes. He has authored over 100 publications and has served on the National Institutes of Health review committees and on the editorial boards of the Journal of Clinical Endocrinology and Metabolism and other endocrine journals.

Research Focus

While working as a research fellow at Harvard in the early 1980s, Dr. Poretsky became known for discovering, describing and characterizing insulin receptors in the human ovary. Dr. Poretsky’s finding established the ovary as a target for regulation by insulin, and introduced a new paradigm of the gonadotropic function of insulin. Poretsky had initially been researching the causes of hyperandrogenism in patients with extreme forms of insulin resistance, for example in women with insulin receptor gene mutations. Subsequently, his work became important for understanding more common disorders, such as polycystic ovary syndrom (PCOS), which affects up to 10% of reproductive age women and is associated with infertility and diabetes. Dr. Poretsky’s work helped lead to the use of insulin-sensitizing agents in patients with PCOS. Dr. Poretsky and his co-workers also characterized related receptors in the ovary (insulin-like growth factor receptors, peroxisome-proliferator activated receptor-gamma), and he conceptualized the insulin-related ovarian regulatory system.

Dr. Poretsky’s other research intents include clinical studies in diabetes and endocrinological aspects of HIV-infection. Current studies involve laboratory work on the efforts of a recently discovered hormone, irisin, in the reproductive system, the poential role of Vitamin D in preventing type 2 diabetes; and developing clinical strategies to reduce readmission rates in patients with diabetes.

Education

First Medical Institute, Leningrad, Russia
Degree: MD
1977

Lab Members

Dimitar Avtanski, PhD
Email: davtanski@northwell.edu
Phone: (212) 434-2971

Publications
  1. Seto-Young D, Avtanski D, Strizhevsky M, Parikh G, Patel P, Kaplun J, Holcomb K, Rosenwaks Z, Poretsky L. “Interactions among peroxisome proliferator activated receptor-g, insulin signaling pathways, and sterodogenic acute regulatory protein in human ovarian cells.” J Clin Endocrinol Metab 92:2232-2239, 2007.
  2. Poretsky L, Song L, Brillon DJ, Ferrando S, Chiu J, McElhiney M, Ferenczi A, Sison C, Haller I, Rabkin J. “Metabolic and hormonal effects of oral DHEA in premenopausal women with HIV infection.” Hormone and Metabolic Research 41:244-249, 2009.
  3. Parikh G, Varadinova M, Suwandhi P, Araki T, Rosenwaks Z, Poretsky L, Seto-Young D. “Vitamin D regulates steroidogenesis and insulin-like growth factor binding protein-1 (IGFBP-1) production in human ovarian cells.” Horm Metab Res 42:754-757, 2010.
  4. Seto-Young D, Avtanski D, Varadinova M, Park A, Suwandhi P, Parikh G, Poretsky L. “Differential roles of MAPK-Erk1/2 and MAPK-p38 in insulin or insulin-like growth factor-I (IGF-I) signaling pathways for progesterone production in human ovarian cells.” Horm Metab Res 43: 386-390, 2011.
  5. Seto-Young D, Avtanski D, Varadinova M, Park A, Suwandhi P, Parikh G, Poretsky L. “Differential roles of MAPK-Erk1/2 and MAPK-p38 in insulin or insulin-like growth factor-I (IGF-I) signaling pathways for progesterone production in human ovarian cells.” Horm Metab Res 43: 386-390, 2011.
  6. Poretsky L. “Polycystic ovary syndrome:  Increased or preserved ovarian sensitivity to insulin?”  J Clin Endocrinol Metab 91:2859-2860, 2006.
  7. Principles of diabetes mellitus, 2nd edition.  L. Poretsky, editor.  Springer, New York, 2010.

View more at PubMed