Lior Brimberg, PhD

Assistant Investigator, Center for Autoimmune and Musculoskeletal Disease,
The Feinstein Institute for Medical Research

Phone: (516) 562-2919
Email: lbrimberg@northwell.edu

About the Investigator

Dr. Lior Brimberg received her PhD from Tel Aviv University in Israel in Neuroimmunology where she studied the link between streptococcus group A infection and neuropsychiatric diseases.  She then continued her post-doctoral studies at Dr. Betty Diamond’s Lab where she is currently studying the effect of maternal anti-brain antibodies on brain development and behavior specifically in Autism Spectrum Disorder.

Research Focus

Since joining Dr. Betty Diamond’s group at The Feinstein Institute for Medical Research, Dr. Lior Brimberg’s research has focused on maternal brain reactive autoantibodies in Autism. Under Dr. Diamond’s guidance she has gathered an extensive data showing  that mothers of an ASD child have an increased frequency of anti-brain antibodies and the presence of these antibodies associated with markers of autoimmunity. Dr. Brimberg and her collages in the lab have been able to isolate and clone those anti-brain antibodies and are currently looking for their targets, and studying the effects of those anti-brain antibodies on brain development and behavior in Autism.

Education

Tel Aviv University, Israel
Degree: BS
2003
Field of Study: Biology and Psychology Special Interdisciplinary Program of neuroscience

Tel Aviv University, Israel
Degree: MA
2005
Field of Study: Psychobiology

Tel Aviv University, Israel
Degree: PhD
2010
Field of Study: Neuroimmunology

Awards & Honors

2015 Selected presentation for press release, Society for Neuroscience, Chicago, IL.
2014 Invited speaker, 2014 world congress, European College of Neuropsychology.
2014 NARSAD Young Investigator Grantee
2014 Post-Doctoral excellence award, Feinstein Institute for Medical Research, Manhasset, NY
2014 Invited speaker, Centricity Series on Neuropsychiatric Manifestations of Autoimmunity & Malignancy, Feinstein Institute for Medical Research, Manhasset, NY
2013 Travel award, Workshop on Autism Spectrum Disorders, Cold Spring Harbor Laboratories, NY
2011 Travel award, European School of Neuroimmunology (ESNI), Glasgow, UK
2009 Travel award, European Federation of Neurological Societies
2008 Excellent PhD students award, Marmoot’s trust, Israel
2008 Travel award, International Congress of Neuroimmunology (ISNI)
2007 Travel award, IGC series workshops, Lisbon Portugal
2007 Travel award, Psychoneuroimmunology Research Society (PNIRS) meeting
2007 Travel award, The Adams super center for brain studies, Israel
2007 Travel award, European School of Neuroimmunology (ESNI), Oxford, UK
2007 Young Investigator award, Israel Foundations Trustees, Israel
2005-2009 Rector Matching Scholarship for excellence, Tel Aviv University
2003-2005 Excellence in Studies, Psychology Department, The Faculty of Social Science. Full Scholarship

Publications
  1. Brimberg, L.; Mader S; Fujieda Y; Arinuma Y; Kowal C and Diamond, B (2015): “Antibodies as mediators of brain disease.” Trends of Immunology, 36 (11), 709-724.
  2.  Lotan, D; Benhar, I; Alvarez, K; Mascaro-Blancoc, A; Brimberg, L; Frenkel, D; Cunningham, M.W; Joel, D (2014): “Behavioral and neural effects of intra-striatal infusion of anti-streptococcal antibodies in rats.” Brain, Behavior and Immunity 38, 249-262.
  3. Brimberg, L., Sadiq A; Gergersen PK., and Diamond B. (2013). “Brain Reactive IgG correlates with autoimmunity in mothers of a child with an Autism Spectrum Disorder.” Molecular Psychiatry, 18(11):1171-7
  4. Diamond, B., Honig, G., Mader, S., Brimberg,L., and  Volpe B.T. (2013) “Brain-Reactive Antibodies and Disease.” Annual Review of Immunology, 31 345-385
  5. Brimberg, L., Benhar, I., Mascaro-Blanco,A., Alvarez, K.,  Winter, C., Klein, J., Moses, E.A., Lotan,D., Somnier,F.E., Leckman, J.F., Swedo, S.E., Cunningham M.W., & Joel, D.(2012). “Behavioral, pharmacological, and immunological abnormalities after streptococcal exposure: A novel rat model of Sydenham chorea and related neuropsychiatric disorders.” Neuropsychopharmacology 37, 2076–2087.
  6. Brimberg, L., Flaisher, S., Schilman, E. & Joel, D. (2007). “Strain differences in ‘compulsive’ lever-pressing.” Behavioral Brain Research, 179(1):141-151.

View more at PubMed