Raj K. Narayan, MD, FACS

Investigator, The Feinstein Institute for Medical Research

Director, Harvey Cushing Institute of Neuroscience, North Shore University Hospital

Chair & Professor of Neurosurgery, Hofstra Northwell School of Medicine

Phone: (516) 562-3816
Email: RNarayan@northwell.edu

About the Investigator

Raj Narayan, MD, FACS, is professor and chairman of the Department of Neurosurgery at Hofstra Northwell School of Medicine and director of the Cushing Neuroscience Institute. He has over 30 years of experience in traumatic brain injury research and is an experienced clinical trials expert.

Dr. Narayan has thus been closely involved with the conception and development of the smart sensor program from its inception. He will supervise Dr. Chunyan Li and the laboratory team in the performance of the proposed studies. He is the principal investigator of the DOD grant that supports the development of the smart sensor. This sensor will be modified to a wireless system as proposed in the present grant.

Dr. Narayan is an internationally recognized expert in the treatment of head injury and has published more than 100 peer-reviewed papers and over 50 book chapters. He also has co-edited the reference textbook Neurotrauma (McGraw-Hill) and helped develop the national evidence-based Guidelines for the Management of Severe Traumatic Brain Injury.

Research Focus

The Cushing Neuromonitoring Lab at The Feinstein Institute for Medical Research, led by Dr. Narayan and Dr. Li, aims to develop the next generation of human monitoring devices using BioMEMS technology, with a particular focus on the monitoring of the injured brain.

Their recent work has focused on the development of a “smart catheter” for the monitoring of multiple physiological parameters simultaneously with a single monitor. Multiple sensors have been incorporated into a single catheter-based device allowing for simultaneous real-time monitoring of multiple measures of brain function. These measures include brain tissue oxygen, blood flow, pressure, temperature, EEG and brain chemistry. It is anticipated that this device will allow clinicians to continuously monitor the milieu within the brain and to make changes whenever there is a physiological imbalance. Thus, Dr. Narayan’s team hopes to create an early warning system that will alert the clinician and hopefully avert secondary brain injury.

In addition, the smart catheter allows for drainage of excess fluid to reduce pressure in the brain. Therefore, both treatment and monitoring of multiple measures are provided in a single device. Once they have completed the engineering of the device, the smart catheters will be tested in small and large animals for safety, accuracy and stability. The accuracy of the sensors will be compared to FDA-approved devices for each of the different measurements. Finally, the device will graduate to trials in patients with traumatic or hemorrhagic brain injury prior to broader military and civilian clinical use.

Lab Members

David Chalif, MD
Director, Neurovascular Neurosurgery

Kenneth Court
Director, Project IS

Eugene V Golanov
Research Scientist

David J Langer
Director, Cerebrovascular Neuro Res

Chunyan Li
Assistant Investigator

Ahmad Latefi
Physician

Danny Liang
Physician

Ricky Madhok
Physician

Rishi Malhotra
Physician

Richard Winn
Physician

Education

Christian Medical College, Vellore, India
Degree: MD
1969-1974
Field of Study: Medicine & Surgery

Medical College of Virginia, Richmond, VA
Degree: Residency
1976-1982
Field of Study: Neurosurgery

National Institutes of Health, Bethesda, MD
Degree: Fellowship
1982-1985
Field of Study: Fellow, Hematology/ Medical Oncology

Appointments

1977-1978 Resident in General Surgery, Medical College of Virginia, Richmond, VA
1978-1982 Resident in Neurosurgery, Medical College of Virginia, Richmond, VA
1982-1985 Staff Neurosurgeon (Special Expert), National Institutes of Health, Bethesda, MD
1985-1989 Assistant Professor of Neurosurgery, Baylor College of Medicine, Houston, TX
1989-1994 Associate Professor of Neurosurgery, Baylor College of Medicine, Houston, TX
1994-1995 Professor of Neurosurgery, Baylor College of Medicine, Houston, TX
1995-2002 Professor and Chairman, Department of Neurosurgery, Temple University School of Medicine, Philadelphia, PA
2002-2009 Frank H. Mayfield Professor and Chairman, Department of Neurosurgery, University of Cincinnati College of Medicine, Cincinnati, OH
2009-present Professor and Chairman, Department of Neurosurgery at Hofstra Northwell School of Medicine and Director, Cushing Neuroscience Institute, Northwell Health

Awards & Honors

1987-1992 Author, Guidelines for the Management of Severe Head Injury
1989-1995 Neurological Devices Panel, U.S. Food and Drug Administration
1990-1992 Consultant, Centers for Disease Control, Panel on Acute Care of Trauma
1990-1992 Chairman, Joint Section on Neurotrauma & Critical Care (AANS/CNS)
1990-present Executive Committee, Joint Section on Neurotrauma & Critical Care (AANS/CNS)
1992-2000 NIH Study Section, Ad Hoc Member, Multiple times for NINDS Guest Examiner, American Board of Neurological Surgery, Multiple times Medical Advisory Board, Brain Trauma Foundation Editorial Board, Neurosurgery
1993-1999 Advance Trauma Life Support (ATLS) Subcommittee
1993-1999 Active Member, Committee on Trauma, American College of Surgeons
1993-2003 Committee on Trauma, American College of Surgeons
1994-1999 National Faculty, Advanced Trauma Life Support
1995-2002 Top Docs in Philadelphia
1997 William Fields Caveness Award, Brain Injury Association
1997-1999 Advisory Council on Neurological Surgery, American College of Surgeons
1999-present Chairman, American Brain Injury Consortium Trauma Technical Advisory Committee to the Texas State Board of Health
2004-2009 Best Doctors in America, Top Docs in Cincinnati
1999-present Chairman, American Brain Injury Consortium
2002-2004 Honorary Member, Alpha Omega Alpha, Epsilon Chapter Chairman, Joint Section on Neurotrauma and Critical Care (AANS/CNS)
2007-present Neurosurgical Consultant, Neurological Emergencies Treatment Trial Network, NINDS

Award for Student Intern Programs
2011 Merit Award (Computer Science), Aseer Amin Hicksville High School
2012 SIMENS Competition Regional Finalist (Math : Science : Technology), Ranjeev Chabra Syosset High School

Publications
  1. Robertson CS, Gopinath SP, Narayan RK, et al: “SjvO2 monitoring in head-injured patients.” J Neurotrauma 12(5):891-896, 1995.
  2. Gopinath SP, Robertson CS, Narayan RK, et al: “Clinical evaluation of a miniature strain-gauge transducer for monitoring intracranial pressure.” Neurosurg 36(6):1137-1140, 1995.
  3. Ritter AM, Gopinath SP, Narayan RK, et al: “Evaluation of a regional oxygen saturation catheter for monitoring SjvO2 in head injured patients.” J Clin Monit 12(4):285-291, 1996.
  4. Narayan RK, Michel ME, Ansell B, et al: “Clinical Trials in Head Injury.” J Neurotrauma 19(5):503-557, 2002.
  5. Li C, Wu PM, Jung W, Ahn CH, Shutter LA, Narayan RK: “A novel lab-on-a-tube for multimodality neuromonitoring of patients with traumatic brain injury (TBI).” Lab Chip 9:1988-1990, 2009.
  6. Li C, Ahn CH, Shutter LA, Narayan RK: “Toward real-time continuous brain glucose and oxygen monitoring with a smart catheter.” Biosens Bioelectron 25:173-178, 2009.
  7. Li C, Wu P-M, Shutter LA and Narayan RK: “Dual Mode operation of flexible piezoelectric polymer diaphragm for intracranial pressure measurement.” Appl Phy Lett 96: 053502, 2010.
  8. Li C, Shutter LA, Pei-Ming Wu, Chong H. Ahn, Narayan RK: “Potential of a simple tab-on-tube for a point of care measurements of multiple analytes.” Lab Chip 10,476–1479, 2010.
  9. Li C, Wu P.M, Hartings J.A, Wu Z, Ahn C.H, LeDoux D, Shutter L.A and Narayan R.K: “Smart catheter flow sensor for real-time continuous regional cerebral blood flow monitoring.” Appl Phy Lett 2011; 99: 233705-233705-4.
  10. Li C, Wu P.M, Wu Z, Ahn C.H, LeDoux D, Shutter L.A, Hartings J.A and Narayan R.K: “Brain temperature measurement: A study of in vitro accuracy and stability of smart catheter temperature sensors.” Biomed Microdevices 2012; 14: 109-118.

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