Colitis (in particular, ulcerative colitis which is limited to the colon) is the inflammation of the inner lining of the colon and can be associated with diarrhea, abdominal pain, bloating, and blood in the stool. In a model of experimental colitis, Feinstein researchers have shown that activation of the vagus nerve reduces these symptoms. Therapies involving the regulation of vagus nerve activity hold promise for the effective treatment of colitis.
- Central muscarinic cholinergic activation alters interaction between splenic dendritic cell and CD4+CD25 T Cells in experimental colitis
Munyaka P, Rabbi MP, Pavlov VA, Tracey KJ, Khafipour E Ghia JE] PLoS One. 2014 Oct 8;9(10):e109272. doi: 10.1371/journal.pone.0109272. eCollection 2014.
- Central cholinergic activation of a vagus nerve – to spleen circuit alleviates experimental colitis
Ji H, Rabbi MF, Labis B, Pavlov VA, Tracey KJ, and Ghia JE. Mucosal Immunol. 2014 Mar;7(2):335-47. doi: 10.1038/mi.2013.52. Epub 2013 Jul 24.
- Expression of Blimp-1 in dendritic cells modulates the innate inflammatory response in dextran sodium sulfate-induced colitis
Kim SJ, Goldstein J, Dorso K, Merad M, Mayer L, Crawford JM, Gregersen PK, Diamond B. Mol Med. 2015 Mar 24; 20:707-19. doi: 10.2119/molmed.2014.00231