Lupus is an autoimmune disease that causes the immune system to lose the ability to differentiate between foreign agents and healthy tissue. It becomes hyperactive and attacks healthy tissue, causing inflammation, swelling, and damage to joints, skin, and internal organs. Feinstein Institute researchers are studying a type of lupus called systemic lupus erythematosus, or SLE, a severe form of lupus that can affect any of the body’s organs. Ongoing studies include the investigation of auto-antibody-mediated brain damage, and the collection of genetic information to identify individuals who are at risk for developing autoimmune disease. Feinstein researchers are developing new therapies for lupus and testing promising new treatments in several clinical trials.

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