Lupus is an autoimmune disease that causes the immune system to lose the ability to differentiate between foreign agents and healthy tissue. It becomes hyperactive and attacks healthy tissue, causing inflammation, swelling, and damage to joints, skin, and internal organs. Feinstein Institute researchers are studying a type of lupus called systemic lupus erythematosus, or SLE, a severe form of lupus that can affect any of the body’s organs. Ongoing studies include the investigation of auto-antibody-mediated brain damage, and the collection of genetic information to identify individuals who are at risk for developing autoimmune disease. Feinstein researchers are developing new therapies for lupus and testing promising new treatments in several clinical trials.
- Neurotoxic lupus autoantibodies alter brain function through two distinct mechanisms Faust TW, Chang EH, Kowal C, Berlin R, Gazaryan IG, Bertini E, Zhang J, Sanchez-Guerrero J, Fragoso-Loyo HE, Volpe BT, Diamond B, and Huerta PT. PNAS 107:18569-74
- Generation of a unique small molecule peptidomimetic that neutralizes lupus autoantibody activity Bloom O, Cheng KF, He M, Paptheodorou A, Volpe BT, Diamond B, and Al-Abed Y. PNAS 108:10255-9 (2011)
- Differences in regional brain activation patterns assessed by functional magnetic resonance imaging in patients with systemic lupus erythematosus stratified by disease duration Mackay M, Bussa MP, Aranow C, Uluğ AM, Volpe BT, Huerta PT, Argyelan M, Mandel A, Hirsch J, Diamond B, Eidelberg D. Mol Med. 2011 Sep 21. doi: 10.2119/molmed.2011.00185. [Epub ahead of print.]
- Neurotoxic autoantibodies mediate congenital impairment of offspring in maternal lupus Nat Lee JY, Huerta PT, Zhang J, Kowal C, Bertini E, Volpe BT, Diamond B. (2009) Med 15(1):91–6.