Metabolic syndrome consists of a group of risk factors (increased blood pressure, a high blood sugar level, excess body fat around the waist and abnormal cholesterol levels) that increase the risk of heart disease. Chronic inflammation, as a result of immune and metabolic dysregulation, is observed in patients with obesity and metabolic syndrome. Feinstein Institute researchers have shown that dysregulation of vagus nerve-mediated anti-inflammatory signaling might contribute to the pathogenesis of obesity and its related comorbidities.
- Galantamine alleviates inflammation and other obesity-associated complications in high-fat diet-fed miceSatapathy SK, Ochani M, Dancho M, Hudson LK, Rosas-Ballina M, Valdes-Ferrer SI, Olofsson PS, Harris YT, Roth J, Chavan S, Tracey KJ, Pavlov VA. Mol Med. 2011;17(7-8):599-606. doi: 10.2119/molmed.2011.00083. Epub 2011 Jul 1.
- The vagus nerve and the inflammatory reflex — linking immunity and metabolismPavlov VA, Tracey KJ. Nat Rev Endocrinol. 2012 Dec;8(12):743-54. Mar 21.