Paralysis affects millions of people worldwide with the two leading causes being stroke and spinal cord injury. Feinstein researchers are currently working to understand how to limit damage and provide a pro-regenerative environment to nerve cells after spinal cord injury. Additional studies are ongoing to identify the molecular factors necessary to successfully recover from central nervous system (CNS) injury or disease.

Bioelectronic devices are also under development to create a neural bypass to circumvent damaged neural pathways resulting from stroke, spinal cord injury, traumatic brain injury, multiple sclerosis (MS), motor neuron disease, and other conditions. It has been shown that intracortically-recorded signals can be decoded to extract information related to motion allowing paralyzed humans to control computers and assistive devices through imagined movements. Recently, further advances have been made to link decoded brain signals directly to movement in a first-in-human demonstration. Researchers are currently looking at ways to extend technology development to address not only paralysis and its comorbidities, but a wide variety of diseases and conditions, leveraging the expanding knowledge within the field of bioelectronic medicine.

Feinstein Institute Investigator Bruce T. Volpe, MD studies the use of robots in stroke recovery. See the video below.

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