Sepsis is the body’s overwhelming and life-threatening response to infection which can lead to tissue damage, organ failure, and death. Researchers at the Feinstein Institute have been researching the causes of sepsis, developing methods of preventing sepsis occurrence and investigating the mechanisms underlying the cognitive and physical impairment that occurs in up to 25% of sepsis survivors. Sepsis represents an opportunity where therapies involving the regulation of vagus nerve activity may hold promising results.
- Xanomeline suppresses excessive pro-inflammatory cytokine responses through neural signal-mediated pathways and improves survival in lethal inflammation Rosas-Ballina M, Valdés-Ferrer SI, Dancho ME, Ochani M, Katz D, Cheng KF, Olofsson PS, Chavan SS, Al-Abed Y, Tracey KJ, Pavlov VA.
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