B Cell Biology

B cells are white blood cells that are produced in the bone marrow and migrate to the spleen and other tissues. They make immunoglobulin, which is a protein used by the immune system to identify and protect against foreign objects such as bacteria and viruses. Defects in the development of B cells or in their function may lead to an overproduction of B cells, which causes a form of leukemia, or to production of antibodies, which leads to autoimmune diseases like lupus or rheumatoid arthritis or lupus.

Feinstein Institute researchers are advancing our understanding about these defects in the development of B cells with the aim of identifying new treatments and diagnostics for diseases such as chronic lymphocytic leukemia and lupus.

Feinstein Institute investigators conducting B cell research include Nicholas Chiorazzi; Anne Davidson; Betty DiamondKanti R. Rai and Ping Wang.