Christine B. Sethna, MD

Division Director, Pediatric Nephrology, Cohen Children’s Medical Center

Associate Professor, Department of Pediatrics, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell

Associate Professor, Center for Pediatric Research, The Feinstein Institute for Medical Research

Phone: (718) 470-3423
Email: csethna@northwell.edu

About the Investigator

Christine Sethna, MD, EdM, is the division director of pediatric nephrology in the Department of Pediatrics at Cohen Children’s Medical Center. Dr. Sethna earned a Bachelors of Arts from Tufts University, a Masters of Education from the Harvard Graduate School of Education and a Doctorate of Medicine from SUNY Downstate School of Medicine. She completed her post-graduate training in general pediatrics and pediatric nephrology at The Children’s Hospital of Philadelphia. As part of her fellowship training, she received a professional certificate in biostatistics and epidemiology from the University of Pennsylvania.

Dr. Sethna’s clinical and research interests focus on hypertension and cardiovascular outcomes in kidney disease, specifically in children with nephrotic syndrome and kidney transplants. She received the designation of nephrotic syndrome specialist from the Nephcure Kidney International Foundation. In addition, Dr. Sethna is the director of resident scholarly activity for the graduate medical education program at CCMC and a member of the Hofstra/Northwell School of Medicine Admissions Committee and Faculty Council. Dr. Sethna is an active member of numerous professional and scientific societies, including the American Society of Pediatric Nephrology (ASPN), American Society of Nephrology and Society for Pediatric Research. Dr. Sethna is the course director for the ASPN Pediatric Nephrology Board Review Course. She was the former section editor of nephrology for American Academy of Pediatrics Grand Rounds and is the current section editor for Frontiers in Pediatrics, Pediatric Nephrology.

The Division of Nephrology at Cohen Children’s Medical Center provides comprehensive diagnostic and treatment services for pediatric kidney diseases and end stage renal disease in children. Under Dr. Sethna’s tenure, the Division of Nephrology has grown in faculty, developed a robust clinical research program, and started a kidney transplant program and a fellowship. The Division is nationally recognized and ranks within the top 50 pediatric nephrology programs in the country by U.S. News & World Report.

Research Focus

The overall focus of Dr. Sethna’s research program is on hypertension and cardiovascular outcomes in children. Specifically, the recent focus has been on cardiovascular outcomes in children with nephrotic syndrome. As a clinical researcher in nephrology, she has served as local PI for several multi-center trials of kidney diseases, including the ongoing NIH-sponsored NEPTUNE and CureGN consortiums. Dr. Sethna is the co-chair of the Cardiovascular Working Group of NEPTUNE and is a member of the Pediatrics Working Group. Dr. Sethna is the PI for an American Heart Association sponsored multi-center ancillary study to evaluate cardiovascular risk factors in children with nephrotic syndrome that are enrolled in NEPTUNE and CureGN. She was a past recipient of a National Kidney Foundation Young Investigator Grant. Dr. Sethna also participates in multiple industry-sponsored studies for treatment of hypertension and nephrotic syndrome. Taken as a whole, Dr. Sethna’s experiences have given her insight into many of the challenges associated with assessing cardiovascular outcomes as well as implementing clinical studies in children.

Lab Members

Kisha Laurent, BS
Research Coordinator
Email: klaurent1@northwell.edu
Phone: 718-470-3423

Rachel Frank, RN
Senior Clinical Research Nurse
Email: rfrank@northwell.edu
Phone:  718-470-3493

Education

Tufts University, Medford, MA
Degree: BA
1997
Field of Study: Child Development

Harvard University Graduate School of Education, Cambridge, MA
Degree: EdM
1998
Field of Study: Child Development Medical Education

SUNY Downstate School of Medicine, Brooklyn, NY
Degree: MD
2002
Field of Study: Medicine

Honors and Awards

1997 Cum Laude with Honors, Tufts University
2001 Alpha Omega Alpha, SUNY Downstate School of Medicine
2002 Magna Cum Laude, SUNY Downstate School of Medicine
2002 AMWA Janet M. Glascow Award for Achievement, SUNY Downstate
2006-2008 NIH Loan Repayment Award for Pediatric Research
2012 Northwell Health Teacher of the Year Award
2013-2015 Northwell Health Physician Leadership Development Program
2013-2014 American Society of Pediatric Nephrology Leadership Development Program
2016-2019 Castle Connolly Top Doctor Award
2017-2018 Castle Connolly Exceptional Women in Medicine Award
2017-2018 New York Magazine Top Doctor Award
2018 American Registry America’s Most Honored Professionals – Top 1% Award

Publications
  1. Gipson D, Troost J, Lafayette R, Hladunewich M, Trachtman H, Gadegbeku C, Sedor J, Holzman L, Moxey-Mims M, Perumal K, Kaskel F, Nelson P, Tuttle K, Bagnasco S, Hogan M, Dell K, Appel G, Lieske J, Ilori T, Sethna C, Fervenza F, Mariani L, Kretzler M and the Nephrotic Syndrome Study Network (NEPTUNE).  Complete Remission in the Nephrotic Syndrome Study Network.   Clin J Am Soc Nephrol. 2016 Jan 7;11(1):81-9
  2. Sethna C., Leisman D.  Left Ventricular Hypertrophy in Children with Hypertension: In Search of a Definition.  Current Hypertension Reports.  2016 Aug;18(8):65
  3. Sethna C, Bryant K, Munshi R, Warady B, Richardson T, Lawlor J, Newland J, Neu A.  Risk Factors for and Outcomes of Peritonitis in Children on Peritoneal Dialysis.  Clin J Am Soc Nephrol.  2016 Sep 7;11(9):1590-6
  4. Guan I, Singer P, Chorny N, Frank R, Infante L, Sethna C.  Role of Race in Kidney Transplant Outcomes in Children with Focal Segmental Glomerulosclerosis.  Pediatric Transplantation. 2016 Sep;20(6):790-7
  5. Nikolis L, Seideman C, Singer P, Chorny N, Frank R, Infante L,  Sethna C Blood Pressure and Urolithiasis in Children.  Journal of Urology.  2017 Feb;13(1):54.e1-54.e6
  6. Gurusinghe S, Singer P, Chorny N, Frank R, Infante L, Sethna C.  Renal Volume and Ambulatory Blood Pressure in Children. Journal of Clinical Hypertension.  2017 May;19(5):498-503
  7. Sethna C, Meyers K, Mariani L, Psoter K, Gadegbeku K, Kretzler M, Brady T.  Blood Pressure and Blood Pressure Variability in Primary Proteinuric Glomerulopathies. Hypertension.  2017 Aug; 70(2):315-323
  8. Sethna C, Merchant K, Reyes A.  Cardiovascular Risk in Children with Kidney Disease.  Seminars in Nephrology.  2018 May Volume 38, No 3, 298-313
  9. Kaur K, Jun D, Grodstein E, Singer P, Teperman L, Molmenti E, Fahmy A, Frank R, Infante L, Sethna C. Effect of Pre-Transplant Obesity, Overweight and Underweight on Pediatric Kidney Transplant OutcomesPediatric Nephrology, 2018 Dec;33(12):2353-2362
  10. Sethna C, Kee D, Casado P, Murphy M, Palmer L, Goreyeb S, Morganstern B. Heterogeneity Index and Echogenicity in Hypertension. Journal of the American Society of Hypertension, 2018 Dec: 12(12) e77-e83
  11. Sethna C, Ng D, Jiang S, Saland J, Furth S, Warady B, Meyers KEC.  Cardiovascular disease risk among children with focal segmental glomerulosclerosis: A report from the Chronic Kidney Disease in Children Study.  Pediatric Nephrology 2019. In Press

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