Assistant Professor, The Center for Biomedical Science, The Feinstein Institute for Medical Research
Assistant Attending, Division of Trauma and Acute Care Surgery, Northwell Health
Assistant Professor, Surgery, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
Phone: (516) 233-3610
Dr. Jared M. Huston is an assistant investigator at The Feinstein Institute for Medical Research. He is also an assistant professor of Surgery at the Zucker School of Medicine and an assistant attending in the Division of Trauma and Acute Care Surgery at Northwell Health. Dr. Huston also serves as the director of Trauma Research for the Department of Surgery.
Prior to joining Northwell Health, Dr. Huston served as an assistant professor of Surgery in the Division of General Surgery, Trauma, Surgical Critical Care and Burns at the Stony Brook School of Medicine. He also served as the director of the Laboratory of Surgical Immunology within the Department of Surgery.
The focus of Dr. Huston’s research group is to understand how the central nervous system maintains homeostasis and protects against traumatic injury. Trauma is a leading cause of death and disability around the world. Two of the most dangerous complications following traumatic injury include bleeding and infection. In the United States, the most common preventable cause of death following traumatic injury is uncontrolled hemorrhage. Therapies to improve hemostasis following injury are limited.
Based on the work of Dr. Kevin Tracey, it is known that the brain monitors and regulates systemic inflammation through the vagus nerve. This pathway is termed the inflammatory reflex, and is comprised of afferent and efferent vagus nerve signaling. The efferent arm of this endogenous neural reflex, referred to as the cholinergic anti-inflammatory pathway, signals through the abdominal vagus nerve and the splenic nerve to target the spleen. Vagus nerve signaling results in release of acetylcholine from a specific subset of T-lymphocytes in the spleen. Acetylcholine can down-regulate pro-inflammatory cytokine production by stimulating the alpha 7 nicotinic acetylcholine receptor subunit on the surface of tissue macrophages. Activation of the cholinergic anti-inflammatory pathway via electrical or mechanical stimulation of the cervical vagus nerve, or via administration of a pharmacological cholinergic agonist, has been shown to prevent lethal organ injury in multiple models of systemic inflammation, shock and sepsis.
Recently, we reported that activation of the inflammatory reflex inhibits experimental post-traumatic hemorrhage. Electrical vagus nerve stimulation significantly reduces total blood loss and time to cessation of bleeding following peripheral soft tissue injury in swine. Vagus nerve stimulation is associated with accelerated clot formation specifically at the site of tissue injury. These findings have also been observed in small animal models of both peripheral and visceral traumatic hemorrhage. Dr. Huston’s research group is currently investigating the mechanisms underlying these observations, with the hope of translating the beneficial effects of vagus nerve stimulation into the clinical arena to improve care of traumatized patients.
Jason R. Fritz, MSBE
Susmita Sarangi, MBBS, MD
Fellow, Pediatric Hematology Oncology
Cohen Children’s Medical Center
Medical Student, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
University of Pennsylvania
Field of Study: Biology
Stony Brook University School of Medicine
Field of Study: Medicine
New York Presbyterian Hospital-Weill Cornell Medical Center
Field of Study: General Surgery
The Feinstein Institute for Medical Research
Field of Study: Neuroimmunology
2010 Outstanding Recent Graduate Award, Stony Brook University School of Medicine
2010-2011 Research and Education Scholarship, American Association for the Surgery of Trauma
2012-2013 Competitive Faculty Award, The Feinstein Institute for Medical Research
2013-2015 Junior Faculty Fellowship, Surgical Infection Society Foundation