Associate Professor, The Center for Autoimmune, Musculoskeletal and Hematopoietic Diseases,
The Feinstein Institute for Medical Research
Phone: (516) 562-0313
Yong-Rui Zou, PhD, is the head of the Laboratory of Hematopoiesis and an associate professor at the Feinstein Institute for Medical Research. She obtained her PhD from Cologne University, Germany in 1994. During her PhD study in Dr. Klaus Rajewsky’s laboratory, she generated the world’s first mouse strain that produced human antibodies. Dr. Zou made significant contributions to the development of the gene targeting technology that is now used worldwide as an essential method to determine biological function of any proteins.
In 1996, Dr. Zou joined Dr. Dan Littman’s laboratory at New York University as a postdoctoral fellow. Her studies showed for the first time that molecules involved in cell trafficking play a critical role in the formation of the brain. Dr. Zou has received a number of honors, including the Howard Hughes postdoctoral fellowship, the Irvington Institute postdoctoral fellowship, the Pew Scholar Award and the Irene Diamond Professorship in Immunology. Dr. Zou was an Assistant Professor of Microbiology at Columbia University from 2001 to 2009. She joined the Feinstein Institute in 2009.
All lineages of leukocytes are generated from the common hematopoietic stem cells (HSC) in the bone marrow. Understanding how HSC differentiate into these lineages and how different leukocytes migrate to various locations to execute their specified functions is thus of paramount important. Dr. Zou’s laboratory has been using and developing genetic and biochemical approaches to identify the mechanisms underlying the formation of lymphoid organs.
The research in the Zou lab includes a focus on HSC function under normal and inflammatory conditions. Our recent studies showed a role for the chemokine receptor CXCR4 in maintaining HSC quiescence. The dormant state of HSCs can be disrupted by inflammatory factors. Furthermore, inflammatory factors, such as HMGB1, skew HSC differentiation potential towards the myeloid over lymphoid lineage. A new lab research area focuses on how inflammatory factors affect the bone morrow microenvironment and differentiation of stromal cells in lymphoid organs in autoimmune diseases.
East China Normal University, China
Field of Study: Biology
Cologne University, Germany
Field of Study: Genetics
Field of Study: Immunology
New York University Medical School
Field of Study: Immunology
Research: Development and function of stromal elements in lymphoid organs.
Phone: (516) 562-0314
Phone: (516) 562-0315
1989 Research Assistantship
1994 NIH visiting fellow
1996 Howard Hughes Fellow
1997 Irvington Institute Fellow
2002 Pew Scholar
2003 Irene Diamond Professorship of Immunology
2004 Sandler Award for Asthma Research
2012 Anita Ross Memorial Educational Award
2013 Innovation Award, AWSM, The Feinstein Institute for Medical Research