Yun Freudenberg-Hua, MD

Assistant Professor, The Litwin-Zucker Center for Alzheimer’s Disease & Memory Disorders,
The Feinstein Institute for Medical Research

Assistant Professor, Psychiatry and Molecular Medicine,
Donald and Barbara Zucker School of Medicine at Hofstra/Northwell

Phone: (516) 562-3492

About the Investigator

Dr. Freudenberg-Hua is an assistant professor of Psychiatry, Molecular Medicine and Genetics at the Litwin Zucker Research Center for Alzheimer’s Disease. She is a faculty member of the Feinstein Institute for Medical Research and the Donald and Barbara Zucker School of Medicine at Hofstra/Northwell. She is also an attending psychiatrist at the Geriatric Center at the Zucker Hillside Hospital.

Dr. Freudenberg-Hua received her medical degree from the University of Hamburg in Germany. Following clinical and research work in Medical Genetics at the University of Bonn School of Medicine, she completed her medical specialization in General and Geriatric Psychiatry at Hofstra Northwell School of Medicine.

Research Focus

Dr. Freudenberg-Hua’s research is focused on identifying genetic risk factors for dementia and neurodegeneration. She compares the genomes of people who suffer from dementia with the genomes of people who remained cognitively healthy at very advanced ages (centenarians and nonagenarians). She applies statistical and bioinformatic methods in genetic data analysis. Her ultimate goal is the translation of genetic research advances into novel ways to prevent and treat dementia.


Hamburg University Medical School
Degree: MD

Institute for Human genetics, University of Bonn
Degree: Residency
Field of Study: Human Genetics

Zucker Hillside Hospital, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
Degree: Residency
Field of Study: Psychiatry

Zucker Hillside Hospital, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
Degree: Fellowship
Field of Study: Geriatric Psychiatry

Awards & Honors

2017 National Institute on Aging /National Institute of Health K08 Award
2017 Davison and Polsky Research Award
2012 NIMH Summer Research Institute in Geriatric Mental Health
2010 Honors Scholar of Geriatric Mental Health Foundation (GMHF)

  1. Freudenberg-Hua Y, Li W, Abhyankar A, Vacic V, Cortes V, Ben-Avraham D, Koppel J, Greenwald B, Germer S, T2D-GENES Consortium, Darnell RB, Barzilai N, Freudenberg J, Atzmon G, Davies P. “Differential burden of rare protein truncating variants in Alzheimer’s disease patients compared to centenarians.” Hum Mol Genet. 2016 Jun 3. pii: ddw150. [Epub ahead of print]
  2. Freudenberg-Hua Y, Freudenberg J, Vacic V, Abhyankar A, Emde AK, Ben-Avraham D, Barzilai N, Oschwald D, Christen E, Koppel J, Greenwald B, Darnell RB, Germer S, Atzmon G, Davies P. “Disease variants in genomes of 44 centenarians.” Mol Genet Genomic Med. 2014;2(5):438-50.
  3. Freudenberg J, Gregersen PK, Freudenberg-Hua Y. “A simple method for analyzing exome sequencing data shows distinct levels of nonsynonymous variation for human immune and nervous system genes.” PLoS One. 2012;7(6):e38087.
  4. Winantea J, Hoang MN, Ohlraun S, Rietschel M, Cichon S, Propping P, Nöthen MM, Freudenberg J, Freudenberg-Hua Y. “A summary statistic approach to sequence variation in noncoding regions of six schizophrenia-associated gene loci.” Eur J Hum Genet. 2006;14:1037-1043.
  5. Freudenberg-Hua Y, Freudenberg J, Kluck N, Cichon S, Propping P, Nothen MM. “Single nucleotide variation analysis in 65 candidate genes for CNS disorders in a representative sample of the European population.” Genome Res. 2003; 13:2271-2276.

View more at PubMed